Abstract
A sensitive time-resolved luminescence method for the determination of flubiprofen (FLP) in methanol and in aqueous solution is described. The method is based on the luminescence sensitization of terbium (Tb3+ ) by the formation of a ternary complex with FLP in the presence of 4,7 diphenyl 1,10 phenanthroline (DPP) as co-ligand, and Tween-20 as surfactant. The signal for Tb-FLP-DPP was monitored at λex = 285 nm and λem = 552 nm. Optimum conditions for the formation of the complex in an aqueous system were TRIS buffer, pH 8.0, DPP (2.5Å~10−7 M), Tween-20 (0.30%) and 4Å~10-5 mol L-1 of Tb3+ which allowed the determination of 20–1000 ng mL-1 of FLP with a limit of detection (LOD) of 10 ng mL-1 . The relative standard deviations of the method ranged between 0.6 and 1.4% indicating excellent reproducibility of the method. The proposed method was successfully applied for the assays of FLP in pharmaceutical formulations and spiked tap water samples with average recoveries of 87% – 95%.
Keywords
Publication details
- DOI
- 10.24200/squjs.vol19iss1pp54-63
- Journal
- Sultan Qaboos University Journal for Science, 19(1), 54
- Publisher
- Sultan Qaboos University
- Open access
- Gold open access
- License
- CC BY 4.0
Cite this article
APA 7
Al‐Kindy, S. M., Al-Ghazali, A., Suliman, F. E. O., & Al-Lawati, H. A. (2014). A Terbium Sensitized Luminescence Method for the Assay of Flubiprofen in Pharmaceutical Formulations. Sultan Qaboos University Journal for Science, 19(1), 54. https://doi.org/10.24200/squjs.vol19iss1pp54-63
MLA 9
Al‐Kindy, Salma M.Z., et al. "A Terbium Sensitized Luminescence Method for the Assay of Flubiprofen in Pharmaceutical Formulations." Sultan Qaboos University Journal for Science, vol. 19, no. 1, 2014, pp. 54. https://doi.org/10.24200/squjs.vol19iss1pp54-63.
Chicago (author–date)
Al‐Kindy, Salma M.Z., Arwa Al-Ghazali, Fakhr Eldin O. Suliman, and Haidar A.J. Al-Lawati. 2014. "A Terbium Sensitized Luminescence Method for the Assay of Flubiprofen in Pharmaceutical Formulations." Sultan Qaboos University Journal for Science 19 (1): 54. https://doi.org/10.24200/squjs.vol19iss1pp54-63.
Harvard
Al‐Kindy, S. M., Al-Ghazali, A., Suliman, F. E. O. and Al-Lawati, H. A. (2014) 'A Terbium Sensitized Luminescence Method for the Assay of Flubiprofen in Pharmaceutical Formulations', Sultan Qaboos University Journal for Science, 19(1), pp. 54. doi:10.24200/squjs.vol19iss1pp54-63.
Vancouver
Al‐Kindy SM, Al-Ghazali A, Suliman FEO, Al-Lawati HA. A Terbium Sensitized Luminescence Method for the Assay of Flubiprofen in Pharmaceutical Formulations. Sultan Qaboos University Journal for Science. 2014;19(1):54. doi:10.24200/squjs.vol19iss1pp54-63
IEEE
S. M. Al‐Kindy, A. Al-Ghazali, F. E. O. Suliman, and H. A. Al-Lawati, "A Terbium Sensitized Luminescence Method for the Assay of Flubiprofen in Pharmaceutical Formulations," Sultan Qaboos University Journal for Science, vol. 19, no. 1, pp. 54, 2014, doi: 10.24200/squjs.vol19iss1pp54-63.