Abstract
Objectives: We sought to investigate the healing efficacy of thermosensitive in situ gelling formulation containing metronidazole and diclofenac potassium on ligature-induced periodontitis (LIP) in rats. Methods: We used 30 adult male Sprague-Dawley rats; 24 rats were subjected to LIP, while the remaining six rats were used as control. The 24 rats with LIP were subdivided into four groups of six rats each. Group 1 received 5% metronidazole loaded gel, group 2 received 0.2% diclofenac potassium loaded gel, group 3 received 5% metronidazole and 0.2% diclofenac potassium, and group 4 (the control group) did not receive any treatment. Treatment was administered on day 0, and the rats were monitored over seven days. Specimens were collected for histological examination to assess the healing process. Results: We found a statistically significant difference (p < 0.050) in the inflammatory and repair parameters of the healing process between different treatments. Combining the two drugs significantly accelerated the healing compared to the drugs given alone. Conclusions: Using a combination of diclofenac and metronidazole could potentially accelerate the healing process compared to the use of a single drug of either diclofenac or metronidazole.
Keywords
Publication details
- DOI
- 10.5001/omj.2022.66
- Journal
- Oman Medical Journal
- Publisher
- Oman Medical Specialty Board
- Open access
- Gold open access
Cite this article
APA 7
Wadi, N. M. A., Ahuja, A., & Peh, K. K. (2022). Healing Enhancement Assessment of Thermosensitive in Situ Gelling Formulation Containing Metronidazole and Diclofenac Potassium for Ligature-induced Periodontitis in Rats. Oman Medical Journal. https://doi.org/10.5001/omj.2022.66
MLA 9
Wadi, Nida M. A., et al. "Healing Enhancement Assessment of Thermosensitive in Situ Gelling Formulation Containing Metronidazole and Diclofenac Potassium for Ligature-induced Periodontitis in Rats." Oman Medical Journal, 2022. https://doi.org/10.5001/omj.2022.66.
Chicago (author–date)
Wadi, Nida M. A., Alka Ahuja, and Kok Khiang Peh. 2022. "Healing Enhancement Assessment of Thermosensitive in Situ Gelling Formulation Containing Metronidazole and Diclofenac Potassium for Ligature-induced Periodontitis in Rats." Oman Medical Journal. https://doi.org/10.5001/omj.2022.66.
Harvard
Wadi, N. M. A., Ahuja, A. and Peh, K. K. (2022) 'Healing Enhancement Assessment of Thermosensitive in Situ Gelling Formulation Containing Metronidazole and Diclofenac Potassium for Ligature-induced Periodontitis in Rats', Oman Medical Journal. doi:10.5001/omj.2022.66.
Vancouver
Wadi NMA, Ahuja A, Peh KK. Healing Enhancement Assessment of Thermosensitive in Situ Gelling Formulation Containing Metronidazole and Diclofenac Potassium for Ligature-induced Periodontitis in Rats. Oman Medical Journal. 2022. doi:10.5001/omj.2022.66
IEEE
N. M. A. Wadi, A. Ahuja, and K. K. Peh, "Healing Enhancement Assessment of Thermosensitive in Situ Gelling Formulation Containing Metronidazole and Diclofenac Potassium for Ligature-induced Periodontitis in Rats," Oman Medical Journal, 2022, doi: 10.5001/omj.2022.66.