Abstract
Objective: The present study was conducted to evaluate the efficacy of Abana® (a poly-ingredient formulation with natural constituents) on in vitro platelet aggregation and occlusion-induced deep venous thrombosis in rats. Methods: Anti-platelet property of Abana® was evaluated using ADP (Adenosin 5′-diphosphate) and adrenaline-induced platelet aggregation models, and anti-thrombotic activity was evaluated against occlusion-induced deep venous thrombosis model in wistar rats. Results: Under the in vitro conditions, Abana® (250, 500 and 1000 µg/ml) alleviated ADP and adrenaline-induced platelet aggregation in a dose-dependent manner. Abana® (1000 µg/ml) inhibited ADP and adrenaline-induced platelet aggregation by as much as 50.69% and 64.83% respectively. Furthermore, 6 days pre-treatment with Abana® (250 and 500 mg/kg, p.o.) in an in vivo study showed significant and dose-dependent protection against occlusion-induced deep venous thrombosis in rats. Conclusion: These findings suggest that Abana®, a polyherbal formulation possesses anti-platelet and anti-thrombotic activities in the experimental models of in vitro platelet aggregation and in vivo deep venous thrombosis in rats.
Keywords
Publication details
- DOI
- 10.5001/omj.2012.127
- Journal
- Oman Medical Journal
- Publisher
- Oman Medical Specialty Board
- Open access
- Gold open access
Cite this article
APA 7
GL, V., Rafiq, M., S, R., KS, S. R., Azeemuddin, M., SD, A., P, R., & PS, P. (2012). Anti-platelet and Anti-thrombotic Effects of a Poly-ingredient formulation: In vitro and in vivo experimental evidences. Oman Medical Journal. https://doi.org/10.5001/omj.2012.127
MLA 9
GL, Viswanatha, et al. "Anti-platelet and Anti-thrombotic Effects of a Poly-ingredient formulation: In vitro and in vivo experimental evidences." Oman Medical Journal, 2012. https://doi.org/10.5001/omj.2012.127.
Chicago (author–date)
GL, Viswanatha, Mohamed Rafiq, Rajesh S, Sandeep Rao KS, Mohammed Azeemuddin, Anturlikar SD, Rangesh P, and Patki PS. 2012. "Anti-platelet and Anti-thrombotic Effects of a Poly-ingredient formulation: In vitro and in vivo experimental evidences." Oman Medical Journal. https://doi.org/10.5001/omj.2012.127.
Harvard
GL, V., Rafiq, M., S, R., KS, S. R., Azeemuddin, M., SD, A., P, R. and PS, P. (2012) 'Anti-platelet and Anti-thrombotic Effects of a Poly-ingredient formulation: In vitro and in vivo experimental evidences', Oman Medical Journal. doi:10.5001/omj.2012.127.
Vancouver
GL V, Rafiq M, S R, KS SR, Azeemuddin M, SD A, et al. Anti-platelet and Anti-thrombotic Effects of a Poly-ingredient formulation: In vitro and in vivo experimental evidences. Oman Medical Journal. 2012. doi:10.5001/omj.2012.127
IEEE
V. GL, M. Rafiq, R. S, S. R. KS, M. Azeemuddin, A. SD, R. P, and P. PS, "Anti-platelet and Anti-thrombotic Effects of a Poly-ingredient formulation: In vitro and in vivo experimental evidences," Oman Medical Journal, 2012, doi: 10.5001/omj.2012.127.