Abstract
Objectives: Carbon nanotubes (CNTs) are allotropes of carbon with a length-to-diameter ratio greater than 10⁶ with the potential uses as medical diagnostic or therapeutic agents. In vitro studies have revealed that gadolinium (Gd) nanoparticle-catalyzed single-walled carbon nanotubes (SWCNTs) possess superparamagnetic properties, which enable them to be used as contrast agents in magnetic resonance imaging (MRI). Our study synthesized Gd-CNT for use as MRI contrast agents. Methods: To reduce the toxicity and solubility of CNTs, it was functionalized, and after loading with Gd was coated with polyethylene glycols (PEG). We then synthesized different concentrations of Gdₙ³⁺@CNTs-PEG and Gadovist® to be evaluated as MRI contrast agents. Results: The analysis showed that the Gd concentration in Gadovist® was 12.18% higher than synthesized Gdₙ³⁺@CNTs-PEG, but the mean signal intensity of the Gdₙ³⁺@CNTs-PEG was approximately 3.3% times higher than Gadovist®. Conclusions: Our findings indicate that synthesized Gdₙ³⁺@CNTs-PEG has the potential to be used as an MRI contrast agent in vitro, but in vivo assessment is necessary to determine the bio-distribution, kinetic, and signal enhancement characteristics.
Keywords
Publication details
- DOI
- 10.5001/omj.2019.27
- Journal
- Oman Medical Journal
- Publisher
- Oman Medical Specialty Board
- Open access
- Gold open access
Cite this article
APA 7
Mehri-Kakavand, G., Hasanzadeh, H., Jahanbakhsh, R., Abdollahi, M., Nasr, R., Bitarafan-Rajabi, A., Jadidi, M., Darbandi-Azar, A., & Emadi, A. (2019). Gdₙ³⁺@CNTs-PEG versus Gadovist®: In Vitro Assay. Oman Medical Journal. https://doi.org/10.5001/omj.2019.27
MLA 9
Mehri-Kakavand, Ghazal, et al. "Gdₙ³⁺@CNTs-PEG versus Gadovist®: In Vitro Assay." Oman Medical Journal, 2019. https://doi.org/10.5001/omj.2019.27.
Chicago (author–date)
Mehri-Kakavand, Ghazal, Hadi Hasanzadeh, Rouzbeh Jahanbakhsh, Maryam Abdollahi, Reza Nasr, Ahmad Bitarafan-Rajabi, Majid Jadidi, Amir Darbandi-Azar, and Alireza Emadi. 2019. "Gdₙ³⁺@CNTs-PEG versus Gadovist®: In Vitro Assay." Oman Medical Journal. https://doi.org/10.5001/omj.2019.27.
Harvard
Mehri-Kakavand, G., Hasanzadeh, H., Jahanbakhsh, R., Abdollahi, M., Nasr, R., Bitarafan-Rajabi, A., Jadidi, M., Darbandi-Azar, A. and Emadi, A. (2019) 'Gdₙ³⁺@CNTs-PEG versus Gadovist®: In Vitro Assay', Oman Medical Journal. doi:10.5001/omj.2019.27.
Vancouver
Mehri-Kakavand G, Hasanzadeh H, Jahanbakhsh R, Abdollahi M, Nasr R, Bitarafan-Rajabi A, et al. Gdₙ³⁺@CNTs-PEG versus Gadovist®: In Vitro Assay. Oman Medical Journal. 2019. doi:10.5001/omj.2019.27
IEEE
G. Mehri-Kakavand, H. Hasanzadeh, R. Jahanbakhsh, M. Abdollahi, R. Nasr, A. Bitarafan-Rajabi, M. Jadidi, A. Darbandi-Azar, and A. Emadi, "Gdₙ³⁺@CNTs-PEG versus Gadovist®: In Vitro Assay," Oman Medical Journal, 2019, doi: 10.5001/omj.2019.27.