[
    {
        "id": "osp-2111",
        "type": "article-journal",
        "title": "Gdₙ³⁺@CNTs-PEG versus Gadovist®: In Vitro Assay",
        "author": [
            {
                "family": "Mehri-Kakavand",
                "given": "Ghazal"
            },
            {
                "family": "Hasanzadeh",
                "given": "Hadi"
            },
            {
                "family": "Jahanbakhsh",
                "given": "Rouzbeh"
            },
            {
                "family": "Abdollahi",
                "given": "Maryam"
            },
            {
                "family": "Nasr",
                "given": "Reza"
            },
            {
                "family": "Bitarafan-Rajabi",
                "given": "Ahmad"
            },
            {
                "family": "Jadidi",
                "given": "Majid"
            },
            {
                "family": "Darbandi-Azar",
                "given": "Amir"
            },
            {
                "family": "Emadi",
                "given": "Alireza"
            }
        ],
        "URL": "https://omanscience.com/en/articles/gd-cnts-peg-versus-gadovist-in-vitro-assay",
        "language": "en",
        "issued": {
            "date-parts": [
                [
                    2019
                ]
            ]
        },
        "container-title": "Oman Medical Journal",
        "DOI": "10.5001/omj.2019.27",
        "publisher": "Oman Medical Specialty Board",
        "ISSN": "1999-768X",
        "abstract": "Objectives: Carbon nanotubes (CNTs) are allotropes of carbon with a length-to-diameter ratio greater than 10⁶ with the potential uses as medical diagnostic or therapeutic agents. In vitro studies have revealed that gadolinium (Gd) nanoparticle-catalyzed single-walled carbon nanotubes (SWCNTs) possess superparamagnetic properties, which enable them to be used as contrast agents in magnetic resonance imaging (MRI). Our study synthesized Gd-CNT for use as MRI contrast agents. Methods: To reduce the toxicity and solubility of CNTs, it was functionalized, and after loading with Gd was coated with polyethylene glycols (PEG). We then synthesized different concentrations of Gdₙ³⁺@CNTs-PEG and Gadovist® to be evaluated as MRI contrast agents. Results: The analysis showed that the Gd concentration in Gadovist® was 12.18% higher than synthesized Gdₙ³⁺@CNTs-PEG, but the mean signal intensity of the Gdₙ³⁺@CNTs-PEG was approximately 3.3% times higher than Gadovist®. Conclusions: Our findings indicate that synthesized Gdₙ³⁺@CNTs-PEG has the potential to be used as an MRI contrast agent in vitro, but in vivo assessment is necessary to determine the bio-distribution, kinetic, and signal enhancement characteristics."
    }
]