Model-guided directed evolution seeks to identify high-fitness protein variants under limited oracle budgets. Protein language models (PLMs) provide rich representations for this task, but task-agnostic zero-shot scores can be misaligned with a target assay, while supervised search in high-dimensional embedding spaces …
Scientific discovery systems typically optimize experiments within a fixed hypothesis space. This creates a failure mode when all available candidates omit the same missing mechanism: candidate disagreement can collapse even while the model class is systematically wrong. We formulate experimental model-class revision, …
Multimodal large language models (MLLMs) often answer visual reasoning questions by relying on linguistic priors rather than task-relevant visual evidence. Textual chain-of-thought reasoning can partially mitigate this issue by encouraging models to decompose visual questions into intermediate evidence-seeking steps, b …