الملخص
Glycyrrhiza glabra (licorice) has been used as an herbal medicine for a long time due to its anti-inflammatory, antioxidant, and antimicrobial properties. Additionally, multiple reports have demonstrated its ability to promote wound healing. Several randomized controlled or clinical trials (RCTs) have demonstrated its potentially therapeutic effects in oral mucosal diseases, especially in recurrent aphthous stomatitis (RAS). This systematic review aims to summarize the evidence for Glycyrrhiza glabra in treating RAS. A systematic search was performed across five databases: PubMed (Medline), ScienceDirect, Scopus document, Cochrane Central Register of Controlled Trials (CENTRAL), and the Cochrane Library Database of Systematic Reviews. This study was reported following the PRISMA guidelines. RCT study using Glycyrrhiza glabra for treating RAS was included in this study with several reported outcomes like changes in ulcer diameter, pain, and healing periods. Seven RCTs were included, which used Glycyrrhiza glabra in the form of patches, pastes, mucoadhesive tablets, and mouthwashes for treating RAS. Glycyrrhiza glabra treatment in various regimens showed significant improvements in pain, ulcer diameter, and healing time in patients with RAS. This review suggests the potential of Glycyrrhiza glabra as an alternative treatment option for RAS.
الكلمات المفتاحية
بيانات النشر
- المعرّف الرقمي
- 10.3390/joma2010008
- المجلة
- مجلة الجمعية الطبية العُمانية, 2(1), 8
- الناشر
- MDPI
- وصول مفتوح
- وصول مفتوح ذهبي
- الترخيص
- CC BY 4.0
اقتبس هذه المقالة
APA 7
Iskandar, A. S., Nisa, G. S. N., Queen, H., Wicaksono, S., Surboyo, M. D. C., & Ernawati, D. S. (2025). Efficacy of Glycyrrhiza glabra in the Treatment of Recurrent Aphthous Stomatitis: A Systematic Review of Randomized Controlled Trials. Journal of the Oman Medical Association, 2(1), 8. https://doi.org/10.3390/joma2010008
MLA 9
Iskandar, Annisa Sabrina, et al. "Efficacy of Glycyrrhiza glabra in the Treatment of Recurrent Aphthous Stomatitis: A Systematic Review of Randomized Controlled Trials." Journal of the Oman Medical Association, vol. 2, no. 1, 2025, pp. 8. https://doi.org/10.3390/joma2010008.
شيكاغو (المؤلف–التاريخ)
Iskandar, Annisa Sabrina, Ghinaya Shaliha Nursaida Nisa, Hanifa Queen, Satutya Wicaksono, Meircurius Dwi Condro Surboyo, and Diah Savitri Ernawati. 2025. "Efficacy of Glycyrrhiza glabra in the Treatment of Recurrent Aphthous Stomatitis: A Systematic Review of Randomized Controlled Trials." Journal of the Oman Medical Association 2 (1): 8. https://doi.org/10.3390/joma2010008.
هارفارد
Iskandar, A. S., Nisa, G. S. N., Queen, H., Wicaksono, S., Surboyo, M. D. C. and Ernawati, D. S. (2025) 'Efficacy of Glycyrrhiza glabra in the Treatment of Recurrent Aphthous Stomatitis: A Systematic Review of Randomized Controlled Trials', Journal of the Oman Medical Association, 2(1), pp. 8. doi:10.3390/joma2010008.
فانكوفر
Iskandar AS, Nisa GSN, Queen H, Wicaksono S, Surboyo MDC, Ernawati DS. Efficacy of Glycyrrhiza glabra in the Treatment of Recurrent Aphthous Stomatitis: A Systematic Review of Randomized Controlled Trials. Journal of the Oman Medical Association. 2025;2(1):8. doi:10.3390/joma2010008
IEEE
A. S. Iskandar, G. S. N. Nisa, H. Queen, S. Wicaksono, M. D. C. Surboyo, and D. S. Ernawati, "Efficacy of Glycyrrhiza glabra in the Treatment of Recurrent Aphthous Stomatitis: A Systematic Review of Randomized Controlled Trials," Journal of the Oman Medical Association, vol. 2, no. 1, pp. 8, 2025, doi: 10.3390/joma2010008.