Abstract
Glycyrrhiza glabra (licorice) has been used as an herbal medicine for a long time due to its anti-inflammatory, antioxidant, and antimicrobial properties. Additionally, multiple reports have demonstrated its ability to promote wound healing. Several randomized controlled or clinical trials (RCTs) have demonstrated its potentially therapeutic effects in oral mucosal diseases, especially in recurrent aphthous stomatitis (RAS). This systematic review aims to summarize the evidence for Glycyrrhiza glabra in treating RAS. A systematic search was performed across five databases: PubMed (Medline), ScienceDirect, Scopus document, Cochrane Central Register of Controlled Trials (CENTRAL), and the Cochrane Library Database of Systematic Reviews. This study was reported following the PRISMA guidelines. RCT study using Glycyrrhiza glabra for treating RAS was included in this study with several reported outcomes like changes in ulcer diameter, pain, and healing periods. Seven RCTs were included, which used Glycyrrhiza glabra in the form of patches, pastes, mucoadhesive tablets, and mouthwashes for treating RAS. Glycyrrhiza glabra treatment in various regimens showed significant improvements in pain, ulcer diameter, and healing time in patients with RAS. This review suggests the potential of Glycyrrhiza glabra as an alternative treatment option for RAS.
Keywords
Publication details
- DOI
- 10.3390/joma2010008
- Journal
- Journal of the Oman Medical Association, 2(1), 8
- Publisher
- MDPI
- Open access
- Gold open access
- License
- CC BY 4.0
Cite this article
APA 7
Iskandar, A. S., Nisa, G. S. N., Queen, H., Wicaksono, S., Surboyo, M. D. C., & Ernawati, D. S. (2025). Efficacy of Glycyrrhiza glabra in the Treatment of Recurrent Aphthous Stomatitis: A Systematic Review of Randomized Controlled Trials. Journal of the Oman Medical Association, 2(1), 8. https://doi.org/10.3390/joma2010008
MLA 9
Iskandar, Annisa Sabrina, et al. "Efficacy of Glycyrrhiza glabra in the Treatment of Recurrent Aphthous Stomatitis: A Systematic Review of Randomized Controlled Trials." Journal of the Oman Medical Association, vol. 2, no. 1, 2025, pp. 8. https://doi.org/10.3390/joma2010008.
Chicago (author–date)
Iskandar, Annisa Sabrina, Ghinaya Shaliha Nursaida Nisa, Hanifa Queen, Satutya Wicaksono, Meircurius Dwi Condro Surboyo, and Diah Savitri Ernawati. 2025. "Efficacy of Glycyrrhiza glabra in the Treatment of Recurrent Aphthous Stomatitis: A Systematic Review of Randomized Controlled Trials." Journal of the Oman Medical Association 2 (1): 8. https://doi.org/10.3390/joma2010008.
Harvard
Iskandar, A. S., Nisa, G. S. N., Queen, H., Wicaksono, S., Surboyo, M. D. C. and Ernawati, D. S. (2025) 'Efficacy of Glycyrrhiza glabra in the Treatment of Recurrent Aphthous Stomatitis: A Systematic Review of Randomized Controlled Trials', Journal of the Oman Medical Association, 2(1), pp. 8. doi:10.3390/joma2010008.
Vancouver
Iskandar AS, Nisa GSN, Queen H, Wicaksono S, Surboyo MDC, Ernawati DS. Efficacy of Glycyrrhiza glabra in the Treatment of Recurrent Aphthous Stomatitis: A Systematic Review of Randomized Controlled Trials. Journal of the Oman Medical Association. 2025;2(1):8. doi:10.3390/joma2010008
IEEE
A. S. Iskandar, G. S. N. Nisa, H. Queen, S. Wicaksono, M. D. C. Surboyo, and D. S. Ernawati, "Efficacy of Glycyrrhiza glabra in the Treatment of Recurrent Aphthous Stomatitis: A Systematic Review of Randomized Controlled Trials," Journal of the Oman Medical Association, vol. 2, no. 1, pp. 8, 2025, doi: 10.3390/joma2010008.