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Background: Chronic urticaria is a complex multifactorial dermatological disease characterized by wheals lasting more than 6 consecutive weeks. The resultant physical discomfort from chronic urticaria may worsen the patient’s quality of life. Emotional manifestations are shown to occur in these patients, among which, d …
In the Editorials of several previous issues, several internal and external factors of the immune system (or body) were mentioned as important factors in immunoregulation. Meanwhile, the main role of immunoregulation in the prevention, control and eradication of various diseases and in protecting individual’s health, a …
Virus-infected cells secrete exosomes and other extracellular vesicles which could deliver viral components, including structural proteins and viral derived-ribonucleic acids to other cells. Released extracellular vesicles carry virus-specific receptors that increase the sensitivity of the target cells to viral infecti …
Sulfur mustard (SM), an alkylating chemical agent, targets several organs, particularly the respiratory system, and results in early and late toxic effects. Currently, there is a considerable lack of adequate medical countermeasures for SM-associated lung injury. Mesenchymal stem cells (MSCs) are characterized by their …
Background: Lung cancer, which is characterized by the presence of malignant tumors, offers a potential avenue for treatment through the use of nanomedicines. Previous in vitro studies have shown promising effects of modified zinc oxide nanoparticles on lung cancer cell lines. Accordingly, this study investigates the i …
Sulfur mustard, a chemical warfare agent, that has been used in the Iraq-Iran conflict, exerts its devastating effects through multifaceted biochemical pathways. Its primary mode of action involves the alkylation of cellular macromolecules, particularly DNA and proteins, leading to cellular dysfunction and damage. DNA …
The immune system plays a critical role in protecting the human body against various pathogens and diseases. Understanding the complexity and dynamics of the immune system is essential for developing effective therapies and interventions. Agent-based modeling (ABM) has emerged as a powerful tool for simulating and stud …
Background: Cancer therapy necessitates innovative approaches with enhanced efficacy and reduced side effects. Essential oils have gained attention because of their diverse biological properties and relatively low toxicity. Zataria multiflora essential oil (ZEO) and Oliveria decumbens essential oil (OEO) exhibit promis …
Background: Given the significant zoonotic threat posed by Salmonella enterica serovar Dublin (S. Dublin) and its substantial impact on animal populations and public health, the objective of the present study was to assess the immunogenicity and protectivity of subcutaneous administration of Salmonella Dublin bacterin …
Intrauterine adhesions (IUAs), also known as Asherman syndrome, is a pathological condition characterized by the development of fibrous scar tissue within the uterine cavity, leading to menstrual abnormalities, infertility, and recurrent pregnancy loss. Current treatment options for IUAs are limited and often associate …