Research article Open access
Arginine-Amino Acid Interactions and Implications to Protein Solubility and Aggregation
Arginine, useful in protein refolding, solubilization of proteins, and suppression of protein aggregation and non-specific adsorption during formulation and purification, is a ubiquitous additive in the biotechnology and pharmaceutical industries. In order to provide a framework for analyzing the molecular level mechan …