Research article Open access
In Silico Design of Novel Anticoagulant Peptides targeting Blood Coagulation Factor VIIa
Objectives: The coagulation cascade initiated during vascular injury prevents bleeding. Unwanted clot formation is however detrimental and requires the use of anticoagulants for prophylaxis and treatment. Anticoagulants targeting a specific step or an enzyme in the clotting process are most preferred as they minimise d …