Review article Open access
The Significance of Matrix Metalloproteinases in the Immunopathogenesis and Treatment of Multiple Sclerosis
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS). The major pathological outcomes of the disease are the loss of blood-brain barrier (BBB) integrity and the development of reactive astrogliosis and MS plaque. For the disease to occur, the non-resident cells must enter into the immune …