Abstract
Background: Pterygium is very common in India and is usually removed by limbal conjunctival autograft transplantation (LCAT), which, despite being the first-line therapy, is still associated with recurrences of up to 18%. Objectives: To compare the safety and efficacy of topical cyclosporine A (CsA) and interferon (IFN) alpha-2b in the prevention of postoperative recurrence of pterygium. Methods: A total of 40 patients with primary pterygium were randomized into two equal groups, Group C and Group I. Both the groups underwent LCAT, with Group C kept on topical cyclosporine 0.05% (CsA) 4 times daily and Group I on topical IFN alpha 2b 0.2 million IU 4 times daily postoperatively for 3 months. Pre- and posttreatment best-corrected visual acuity (BCVA), recurrence, and complications were assessed at day 1, week 1, 1 month, and 3 months. Results: The mean preoperative BCVA of 0.51 ± 0.18 and 0.51 ± 0.23 improved to 0.13 ± 0.13 and 0.13 ± 0.13 in Group C and Group I, respectively, after 3 months of treatment (P < 0.0001). Recurrence was seen in 2 cases in Group C and in 1 case in Group I at 3 months. No significant complications occurred in either of the groups. Conclusion: Topical CsA and IFN Alpha-2b are newer efficacious adjuvants with LCAT for prevention of postoperative pterygium recurrence.
Keywords
Publication details
- DOI
- 10.4103/ojo.ojo_56_22
- Journal
- Oman Journal of Ophthalmology, 16(1), 30-34
- Publisher
- Medknow Publications
- Open access
- Gold open access
Cite this article
APA 7
Raina, U. K., Pavitra, B., Bhattacharya, S., Ravinesh, K., & Goel, R. (2023). Topical cyclosporine A and interferon alpha-2b as adjuvants to surgery to decrease pterygium recurrence. Oman Journal of Ophthalmology, 16(1), 30-34. https://doi.org/10.4103/ojo.ojo_56_22
MLA 9
Raina, Usha K, et al. "Topical cyclosporine A and interferon alpha-2b as adjuvants to surgery to decrease pterygium recurrence." Oman Journal of Ophthalmology, vol. 16, no. 1, 2023, pp. 30-34. https://doi.org/10.4103/ojo.ojo_56_22.
Chicago (author–date)
Raina, Usha K, Banu Pavitra, Shruti Bhattacharya, Kumar Ravinesh, and Ruchi Goel. 2023. "Topical cyclosporine A and interferon alpha-2b as adjuvants to surgery to decrease pterygium recurrence." Oman Journal of Ophthalmology 16 (1): 30-34. https://doi.org/10.4103/ojo.ojo_56_22.
Harvard
Raina, U. K., Pavitra, B., Bhattacharya, S., Ravinesh, K. and Goel, R. (2023) 'Topical cyclosporine A and interferon alpha-2b as adjuvants to surgery to decrease pterygium recurrence', Oman Journal of Ophthalmology, 16(1), pp. 30-34. doi:10.4103/ojo.ojo_56_22.
Vancouver
Raina UK, Pavitra B, Bhattacharya S, Ravinesh K, Goel R. Topical cyclosporine A and interferon alpha-2b as adjuvants to surgery to decrease pterygium recurrence. Oman Journal of Ophthalmology. 2023;16(1):30-34. doi:10.4103/ojo.ojo_56_22
IEEE
U. K. Raina, B. Pavitra, S. Bhattacharya, K. Ravinesh, and R. Goel, "Topical cyclosporine A and interferon alpha-2b as adjuvants to surgery to decrease pterygium recurrence," Oman Journal of Ophthalmology, vol. 16, no. 1, pp. 30-34, 2023, doi: 10.4103/ojo.ojo_56_22.