[
    {
        "id": "osp-12200",
        "type": "article-journal",
        "title": "Topical cyclosporine A and interferon alpha-2b as adjuvants to surgery to decrease pterygium recurrence",
        "author": [
            {
                "family": "Raina",
                "given": "Usha K"
            },
            {
                "family": "Pavitra",
                "given": "Banu"
            },
            {
                "family": "Bhattacharya",
                "given": "Shruti"
            },
            {
                "family": "Ravinesh",
                "given": "Kumar"
            },
            {
                "family": "Goel",
                "given": "Ruchi"
            }
        ],
        "URL": "https://omanscience.com/en/articles/topical-cyclosporine-a-and-interferon-alpha-2b-as-adjuvants-to-surgery-to-decrease-pterygium-recurrence",
        "language": "en",
        "issued": {
            "date-parts": [
                [
                    2023
                ]
            ]
        },
        "container-title": "Oman Journal of Ophthalmology",
        "volume": "16",
        "issue": "1",
        "page": "30-34",
        "DOI": "10.4103/ojo.ojo_56_22",
        "publisher": "Medknow Publications",
        "ISSN": "0974-620X",
        "abstract": "Background: Pterygium is very common in India and is usually removed by limbal conjunctival autograft transplantation (LCAT), which, despite being the first-line therapy, is still associated with recurrences of up to 18%.\n\nObjectives: To compare the safety and efficacy of topical cyclosporine A (CsA) and interferon (IFN) alpha-2b in the prevention of postoperative recurrence of pterygium.\n\nMethods: A total of 40 patients with primary pterygium were randomized into two equal groups, Group C and Group I. Both the groups underwent LCAT, with Group C kept on topical cyclosporine 0.05% (CsA) 4 times daily and Group I on topical IFN alpha 2b 0.2 million IU 4 times daily postoperatively for 3 months. Pre- and posttreatment best-corrected visual acuity (BCVA), recurrence, and complications were assessed at day 1, week 1, 1 month, and 3 months.\n\nResults: The mean preoperative BCVA of 0.51 ± 0.18 and 0.51 ± 0.23 improved to 0.13 ± 0.13 and 0.13 ± 0.13 in Group C and Group I, respectively, after 3 months of treatment (P < 0.0001). Recurrence was seen in 2 cases in Group C and in 1 case in Group I at 3 months. No significant complications occurred in either of the groups.\n\nConclusion: Topical CsA and IFN Alpha-2b are newer efficacious adjuvants with LCAT for prevention of postoperative pterygium recurrence."
    }
]