Abstract
This systematic review indicates that hydroxyurea may be a promising pharmacologic option for leukoreduction in paediatric critical pertussis. In reported cases, hydroxyurea was associated with leukocyte reduction and short-term survival. Its ability to potentially reduce the need for invasive leukoreductive procedures is especially relevant in resource-limited settings. While these observations are encouraging, the evidence base remains limited to a small number of uncontrolled case reports and case series, with inconsistent safety monitoring and no long-term follow-up. Given the very low certainty of the available evidence, these results should be considered preliminary and hypothesis-generating. Further well-designed, multicentre studies and randomised trials are urgently needed to confirm whether hydroxyurea can fulfil its potential as an effective and safe adjunctive treatment for this high-risk population.
Publication details
- DOI
- 10.18295/2075-0528.2937
- Journal
- Sultan Qaboos University Medical Journal, 25(1), 1135-1143
- Publisher
- Sultan Qaboos University
- Open access
- Gold open access
- License
- CC BY-ND 4.0
Cite this article
APA 7
Alhamoud, A. H., Suhaqi, M. Y., Arishi, Q. A., Somili, F. Y., Gohal, H. M., Almalki, A. S., Eidoh, M. A., & Hazazi, F. Y. (2025). Therapeutic Role of Hydroxyurea in Paediatric Hydroxyurea Pertussis: A systematic review. Sultan Qaboos University Medical Journal, 25(1), 1135-1143. https://doi.org/10.18295/2075-0528.2937
MLA 9
Alhamoud, Abdullah H., et al. "Therapeutic Role of Hydroxyurea in Paediatric Hydroxyurea Pertussis: A systematic review." Sultan Qaboos University Medical Journal, vol. 25, no. 1, 2025, pp. 1135-1143. https://doi.org/10.18295/2075-0528.2937.
Chicago (author–date)
Alhamoud, Abdullah H., Mohammed Y. Suhaqi, Qasem A. Arishi, Fahd Y. Somili, Hassan M. Gohal, Abdulaziz S. Almalki, Mohammed A. Eidoh, and Fadhel Y. Hazazi. 2025. "Therapeutic Role of Hydroxyurea in Paediatric Hydroxyurea Pertussis: A systematic review." Sultan Qaboos University Medical Journal 25 (1): 1135-1143. https://doi.org/10.18295/2075-0528.2937.
Harvard
Alhamoud, A. H., Suhaqi, M. Y., Arishi, Q. A., Somili, F. Y., Gohal, H. M., Almalki, A. S., Eidoh, M. A. and Hazazi, F. Y. (2025) 'Therapeutic Role of Hydroxyurea in Paediatric Hydroxyurea Pertussis: A systematic review', Sultan Qaboos University Medical Journal, 25(1), pp. 1135-1143. doi:10.18295/2075-0528.2937.
Vancouver
Alhamoud AH, Suhaqi MY, Arishi QA, Somili FY, Gohal HM, Almalki AS, et al. Therapeutic Role of Hydroxyurea in Paediatric Hydroxyurea Pertussis: A systematic review. Sultan Qaboos University Medical Journal. 2025;25(1):1135-1143. doi:10.18295/2075-0528.2937
IEEE
A. H. Alhamoud, M. Y. Suhaqi, Q. A. Arishi, F. Y. Somili, H. M. Gohal, A. S. Almalki, M. A. Eidoh, and F. Y. Hazazi, "Therapeutic Role of Hydroxyurea in Paediatric Hydroxyurea Pertussis: A systematic review," Sultan Qaboos University Medical Journal, vol. 25, no. 1, pp. 1135-1143, 2025, doi: 10.18295/2075-0528.2937.