[
    {
        "id": "osp-9925",
        "type": "article-journal",
        "title": "Therapeutic Role of Hydroxyurea in Paediatric Hydroxyurea Pertussis: A systematic review",
        "author": [
            {
                "family": "Alhamoud",
                "given": "Abdullah H."
            },
            {
                "family": "Suhaqi",
                "given": "Mohammed Y."
            },
            {
                "family": "Arishi",
                "given": "Qasem A."
            },
            {
                "family": "Somili",
                "given": "Fahd Y."
            },
            {
                "family": "Gohal",
                "given": "Hassan M."
            },
            {
                "family": "Almalki",
                "given": "Abdulaziz S."
            },
            {
                "family": "Eidoh",
                "given": "Mohammed A."
            },
            {
                "family": "Hazazi",
                "given": "Fadhel Y."
            }
        ],
        "URL": "https://omanscience.com/en/articles/therapeutic-role-of-hydroxyurea-in-paediatric-hydroxyurea-pertussis-a-systematic-review",
        "language": "en",
        "issued": {
            "date-parts": [
                [
                    2025
                ]
            ]
        },
        "container-title": "Sultan Qaboos University Medical Journal",
        "volume": "25",
        "issue": "1",
        "page": "1135-1143",
        "DOI": "10.18295/2075-0528.2937",
        "publisher": "Sultan Qaboos University",
        "ISSN": "2075-051X",
        "abstract": "This systematic review indicates that hydroxyurea may be a promising pharmacologic option for leukoreduction in paediatric critical pertussis. In reported cases, hydroxyurea was associated with leukocyte reduction and short-term survival. Its ability to potentially reduce the need for invasive leukoreductive procedures is especially relevant in resource-limited settings. While these observations are encouraging, the evidence base remains limited to a small number of uncontrolled case reports and case series, with inconsistent safety monitoring and no long-term follow-up. Given the very low certainty of the available evidence, these results should be considered preliminary and hypothesis-generating. Further well-designed, multicentre studies and randomised trials are urgently needed to confirm whether hydroxyurea can fulfil its potential as an effective and safe adjunctive treatment for this high-risk population."
    }
]