Abstract
Objectives: Proton pump inhibitors (PPIs) are among the most widely prescribed drugs for long-term suppression of gastric acid. Though generally considered safe, increasing evidence links their use to altered bone metabolism. This systematic review investigates the hypothesis that PPI-induced inhibition on PHOSPHO1-a bone-specific phosphatase- impairs bone mineralisation. Methods: A systematic electronic search was conducted for experimental studies from January 2000 to January 2025. The screening and selection followed PRISMA guidelines. Results: Of 20 articles identified, 3 met the inclusion criteria: two in-vitro studies and one combining both in-vitro and in-vivo data. All three examined the effects of PPIs on bone formation and consistently reported significantly reduced minerallization capacity. Conclusion: The review suggests that PPIs appear to inhibit PHOSPHO1 activity, potentially impairing early-stage bone mineralisation. However, due to the limited number of studies, these findings should be interpreted with caution, and further research is warranted.
Publication details
- DOI
- 10.18295/2075-0528.2920
- Journal
- Sultan Qaboos University Medical Journal, 25(1), 974-980
- Publisher
- Sultan Qaboos University
- Open access
- Gold open access
- License
- CC BY-ND 4.0
Cite this article
APA 7
Baudin, C., & Faria-Almeida, R. (2025). The Effect of Proton Pump Inhibitors on Bone Mineralisation: A Systematic Review with Focus on PHOSPHO1. Sultan Qaboos University Medical Journal, 25(1), 974-980. https://doi.org/10.18295/2075-0528.2920
MLA 9
Baudin, Célia, and Ricardo Faria-Almeida. "The Effect of Proton Pump Inhibitors on Bone Mineralisation: A Systematic Review with Focus on PHOSPHO1." Sultan Qaboos University Medical Journal, vol. 25, no. 1, 2025, pp. 974-980. https://doi.org/10.18295/2075-0528.2920.
Chicago (author–date)
Baudin, Célia, and Ricardo Faria-Almeida. 2025. "The Effect of Proton Pump Inhibitors on Bone Mineralisation: A Systematic Review with Focus on PHOSPHO1." Sultan Qaboos University Medical Journal 25 (1): 974-980. https://doi.org/10.18295/2075-0528.2920.
Harvard
Baudin, C. and Faria-Almeida, R. (2025) 'The Effect of Proton Pump Inhibitors on Bone Mineralisation: A Systematic Review with Focus on PHOSPHO1', Sultan Qaboos University Medical Journal, 25(1), pp. 974-980. doi:10.18295/2075-0528.2920.
Vancouver
Baudin C, Faria-Almeida R. The Effect of Proton Pump Inhibitors on Bone Mineralisation: A Systematic Review with Focus on PHOSPHO1. Sultan Qaboos University Medical Journal. 2025;25(1):974-980. doi:10.18295/2075-0528.2920
IEEE
C. Baudin, and R. Faria-Almeida, "The Effect of Proton Pump Inhibitors on Bone Mineralisation: A Systematic Review with Focus on PHOSPHO1," Sultan Qaboos University Medical Journal, vol. 25, no. 1, pp. 974-980, 2025, doi: 10.18295/2075-0528.2920.