Abstract
Objectives: Obesity increases the risk of numerous chronic diseases. Obesity is classified clinically using body mass index (BMI), waist-to-hip ratio, and body fat percentage. The lipoprotein lipase (LPL) gene has been linked to lipoprotein metabolism and obesity. We performed a case-control study to determine the association between LPL gene polymorphisms and obesity-associated phenotypes such as insulin resistance (IR). Methods: We examined the different LPL gene variants for association in 642 individuals segregated by BMI and IR. Genotyping of the LPL gene -93 and -53 promoter gene polymorphisms were analyzed using polymerase chain reaction-restriction fragment length polymorphism. Results: A substantial association was observed for -93 gene polymorphism of the LPL gene with obesity, while -53 promoter gene polymorphism showed association with IR. Conclusions: We found a significant association between -93 and -53 promoter gene polymorphisms of the LPL gene with obesity and associated phenotypes in the studied population.
Keywords
Publication details
- DOI
- 10.5001/omj.2018.74
- Journal
- Oman Medical Journal
- Publisher
- Oman Medical Specialty Board
- Open access
- Gold open access
Cite this article
APA 7
Prakash, J., Mittal, B., Srivastava, A., Awasthi, S., & Srivastava, N. (2018). The Association of a Rare Variant of -93, -53 Promoter Gene Polymorphisms of Lipoprotein Lipase Gene with Obesity and Insulin Resistance. Oman Medical Journal. https://doi.org/10.5001/omj.2018.74
MLA 9
Prakash, Jai, et al. "The Association of a Rare Variant of -93, -53 Promoter Gene Polymorphisms of Lipoprotein Lipase Gene with Obesity and Insulin Resistance." Oman Medical Journal, 2018. https://doi.org/10.5001/omj.2018.74.
Chicago (author–date)
Prakash, Jai, Balraj Mittal, Apurva Srivastava, Shally Awasthi, and Neena Srivastava. 2018. "The Association of a Rare Variant of -93, -53 Promoter Gene Polymorphisms of Lipoprotein Lipase Gene with Obesity and Insulin Resistance." Oman Medical Journal. https://doi.org/10.5001/omj.2018.74.
Harvard
Prakash, J., Mittal, B., Srivastava, A., Awasthi, S. and Srivastava, N. (2018) 'The Association of a Rare Variant of -93, -53 Promoter Gene Polymorphisms of Lipoprotein Lipase Gene with Obesity and Insulin Resistance', Oman Medical Journal. doi:10.5001/omj.2018.74.
Vancouver
Prakash J, Mittal B, Srivastava A, Awasthi S, Srivastava N. The Association of a Rare Variant of -93, -53 Promoter Gene Polymorphisms of Lipoprotein Lipase Gene with Obesity and Insulin Resistance. Oman Medical Journal. 2018. doi:10.5001/omj.2018.74
IEEE
J. Prakash, B. Mittal, A. Srivastava, S. Awasthi, and N. Srivastava, "The Association of a Rare Variant of -93, -53 Promoter Gene Polymorphisms of Lipoprotein Lipase Gene with Obesity and Insulin Resistance," Oman Medical Journal, 2018, doi: 10.5001/omj.2018.74.