[
    {
        "id": "osp-2048",
        "type": "article-journal",
        "title": "The Association of a Rare Variant of -93, -53 Promoter Gene Polymorphisms of Lipoprotein Lipase Gene with Obesity and Insulin Resistance",
        "author": [
            {
                "family": "Prakash",
                "given": "Jai"
            },
            {
                "family": "Mittal",
                "given": "Balraj"
            },
            {
                "family": "Srivastava",
                "given": "Apurva"
            },
            {
                "family": "Awasthi",
                "given": "Shally"
            },
            {
                "family": "Srivastava",
                "given": "Neena"
            }
        ],
        "URL": "https://omanscience.com/en/articles/the-association-of-a-rare-variant-of-93-53-promoter-gene-polymorphisms-of-lipoprotein-lipase-gene-with-obesity-and-insulin-resistance",
        "language": "en",
        "issued": {
            "date-parts": [
                [
                    2018
                ]
            ]
        },
        "container-title": "Oman Medical Journal",
        "DOI": "10.5001/omj.2018.74",
        "publisher": "Oman Medical Specialty Board",
        "ISSN": "1999-768X",
        "abstract": "Objectives: Obesity increases the risk of numerous chronic diseases. Obesity is classified clinically using body mass index (BMI), waist-to-hip ratio, and body fat percentage. The lipoprotein lipase (LPL) gene has been linked to lipoprotein metabolism and obesity. We performed a case-control study to determine the association between LPL gene polymorphisms and obesity-associated phenotypes such as insulin resistance (IR). Methods: We examined the different LPL gene variants for association in 642 individuals segregated by BMI and IR. Genotyping of the LPL gene -93 and -53 promoter gene polymorphisms were analyzed using polymerase chain reaction-restriction fragment length polymorphism. Results: A substantial association was observed for -93 gene polymorphism of the LPL gene with obesity, while -53 promoter gene polymorphism showed association with IR. Conclusions: We found a significant association between -93 and -53 promoter gene polymorphisms of the LPL gene with obesity and associated phenotypes in the studied population."
    }
]