Abstract
Tenofovir, a nucleotide analog, is one of the first-line medications recommended for the treatment of active chronic hepatitis B virus infection (CHB) and as a primary prophylaxis to prevent hepatitis B reactivation in cases of immunosuppression. We report the first case of tenofovir-induced leukocytoclastic vasculitis (LCV). A 43-year-old obese woman, who was known to have inactive CHB, was diagnosed with chronic immune thrombocytopenic purpura (ITP). She was treated with corticosteroid therapy and was put on tenofovir to prevent hepatitis B virus reactivation. A month later, she developed a skin rash, described as non-blanchable well-defined erythematous to violaceous papules and targetoid patches in her lower extremities. A skin biopsy showed features of LCV. The rash resolved completely within few days after replacing tenofovir with entecavir.
Keywords
Publication details
- DOI
- 10.5001/omj.2017.80
- Journal
- Oman Medical Journal
- Publisher
- Oman Medical Specialty Board
- Open access
- Gold open access
Cite this article
APA 7
Al-Busafi, S. A., Al-Suleimani, A., Al-Hamadani, A., & Rasool, W. (2017). Tenofovir-induced Leukocytoclastic Vasculitis. Oman Medical Journal. https://doi.org/10.5001/omj.2017.80
MLA 9
Al-Busafi, Said A., et al. "Tenofovir-induced Leukocytoclastic Vasculitis." Oman Medical Journal, 2017. https://doi.org/10.5001/omj.2017.80.
Chicago (author–date)
Al-Busafi, Said A., Abdulatif Al-Suleimani, Aysha Al-Hamadani, and Wasif Rasool. 2017. "Tenofovir-induced Leukocytoclastic Vasculitis." Oman Medical Journal. https://doi.org/10.5001/omj.2017.80.
Harvard
Al-Busafi, S. A., Al-Suleimani, A., Al-Hamadani, A. and Rasool, W. (2017) 'Tenofovir-induced Leukocytoclastic Vasculitis', Oman Medical Journal. doi:10.5001/omj.2017.80.
Vancouver
Al-Busafi SA, Al-Suleimani A, Al-Hamadani A, Rasool W. Tenofovir-induced Leukocytoclastic Vasculitis. Oman Medical Journal. 2017. doi:10.5001/omj.2017.80
IEEE
S. A. Al-Busafi, A. Al-Suleimani, A. Al-Hamadani, and W. Rasool, "Tenofovir-induced Leukocytoclastic Vasculitis," Oman Medical Journal, 2017, doi: 10.5001/omj.2017.80.