Abstract
The frequency of Rhesus D negative blood group in Omanis is 8.35% but the molecular background of this phenotype is unknown in the Omani population. The Rhesus D negative phenotype has a high molecular diversity. We report a rare case of serological D negative with existence of complete RHD gene in a 43-year-old Omani male blood donor. Molecular analysis of RHD exons showed duplication across the boundary of intron 3 and exon 4. This is a 37 bp insert in RHD exon 4 along with c.609 G>A mutation. We are uncertain if the presence of RHDΨ is homozygous (RHDΨ/RHDΨ) or hemizygous (RHDΨ/del). Therefore, molecular basis of D zygosity determination would be a good approach to further explore the case.
Keywords
Publication details
- DOI
- 10.5001/omj.2023.11
- Journal
- Oman Medical Journal
- Publisher
- Oman Medical Specialty Board
- Open access
- Gold open access
Cite this article
APA 7
Al-Lawati, M., & Al Balushi, B. (2023). RHD Positive Haplotype in D Negative Omani Blood Donor. Oman Medical Journal. https://doi.org/10.5001/omj.2023.11
MLA 9
Al-Lawati, Mujtaba, and Badriya Al Balushi. "RHD Positive Haplotype in D Negative Omani Blood Donor." Oman Medical Journal, 2023. https://doi.org/10.5001/omj.2023.11.
Chicago (author–date)
Al-Lawati, Mujtaba, and Badriya Al Balushi. 2023. "RHD Positive Haplotype in D Negative Omani Blood Donor." Oman Medical Journal. https://doi.org/10.5001/omj.2023.11.
Harvard
Al-Lawati, M. and Al Balushi, B. (2023) 'RHD Positive Haplotype in D Negative Omani Blood Donor', Oman Medical Journal. doi:10.5001/omj.2023.11.
Vancouver
Al-Lawati M, Al Balushi B. RHD Positive Haplotype in D Negative Omani Blood Donor. Oman Medical Journal. 2023. doi:10.5001/omj.2023.11
IEEE
M. Al-Lawati, and B. Al Balushi, "RHD Positive Haplotype in D Negative Omani Blood Donor," Oman Medical Journal, 2023, doi: 10.5001/omj.2023.11.