Abstract
Sarcoidosis is an idiopathic multisystem inflammatory disorder characterised by non-caseating granulomas and a wide range of reported prevalence. Renal-limited sarcoidosis is a rare manifestation of sarcoidosis which remains a diagnostic challenge due to lack of extra renal manifestation and specific diagnostic criteria. We report a 37-year-old man who presented to a tertiary care hospital, Muscat, Oman, in 2024, with a two-month history of fever, weight loss, hypercalcaemia, high-to-normal 1,25-Vitamin D, high angiotensin-converting enzyme levels and acute kidney injury. His renal biopsy showed evidence of tubulointerstitial nephritis without granulomas or nephrocalcinosis. After exclusion of infectious, malignant, drug- related and autoimmune causes, a probable diagnosis of renal-limited sarcoidosis was considered. The patient received a course of steroids with subsequent improvement in his symptoms, renal function and renal biopsy inflammatory activity. This case highlights the diagnostic uncertainty and challenges in renal-limited sarcoidosis, particularly in the absence of granulomatous inflammation.
Publication details
- DOI
- 10.18295/2075-0528.3004
- Journal
- Sultan Qaboos University Medical Journal, 26(1), 466-471
- Publisher
- Sultan Qaboos University
- Open access
- Gold open access
- License
- CC BY-ND 4.0
Cite this article
APA 7
AlNoumani, J. H., Shoaib, M., Marzouqi, A., & Al-Lawati, A. (2026). Probable Renal-Limited Sarcoidosis Presenting With Tubulointerstitial Nephritis Without Granulomas on Renal Biopsy: A diagnostic challenge. Sultan Qaboos University Medical Journal, 26(1), 466-471. https://doi.org/10.18295/2075-0528.3004
MLA 9
AlNoumani, Jawahar Hamood, et al. "Probable Renal-Limited Sarcoidosis Presenting With Tubulointerstitial Nephritis Without Granulomas on Renal Biopsy: A diagnostic challenge." Sultan Qaboos University Medical Journal, vol. 26, no. 1, 2026, pp. 466-471. https://doi.org/10.18295/2075-0528.3004.
Chicago (author–date)
AlNoumani, Jawahar Hamood, Muhammad Shoaib, Asma Marzouqi, and Ali Al-Lawati. 2026. "Probable Renal-Limited Sarcoidosis Presenting With Tubulointerstitial Nephritis Without Granulomas on Renal Biopsy: A diagnostic challenge." Sultan Qaboos University Medical Journal 26 (1): 466-471. https://doi.org/10.18295/2075-0528.3004.
Harvard
AlNoumani, J. H., Shoaib, M., Marzouqi, A. and Al-Lawati, A. (2026) 'Probable Renal-Limited Sarcoidosis Presenting With Tubulointerstitial Nephritis Without Granulomas on Renal Biopsy: A diagnostic challenge', Sultan Qaboos University Medical Journal, 26(1), pp. 466-471. doi:10.18295/2075-0528.3004.
Vancouver
AlNoumani JH, Shoaib M, Marzouqi A, Al-Lawati A. Probable Renal-Limited Sarcoidosis Presenting With Tubulointerstitial Nephritis Without Granulomas on Renal Biopsy: A diagnostic challenge. Sultan Qaboos University Medical Journal. 2026;26(1):466-471. doi:10.18295/2075-0528.3004
IEEE
J. H. AlNoumani, M. Shoaib, A. Marzouqi, and A. Al-Lawati, "Probable Renal-Limited Sarcoidosis Presenting With Tubulointerstitial Nephritis Without Granulomas on Renal Biopsy: A diagnostic challenge," Sultan Qaboos University Medical Journal, vol. 26, no. 1, pp. 466-471, 2026, doi: 10.18295/2075-0528.3004.