[
    {
        "id": "osp-9894",
        "type": "article-journal",
        "title": "Probable Renal-Limited Sarcoidosis Presenting With Tubulointerstitial Nephritis Without Granulomas on Renal Biopsy: A diagnostic challenge",
        "author": [
            {
                "family": "AlNoumani",
                "given": "Jawahar Hamood"
            },
            {
                "family": "Shoaib",
                "given": "Muhammad"
            },
            {
                "family": "Marzouqi",
                "given": "Asma"
            },
            {
                "family": "Al-Lawati",
                "given": "Ali"
            }
        ],
        "URL": "https://omanscience.com/en/articles/probable-renal-limited-sarcoidosis-presenting-with-tubulointerstitial-nephritis-without-granulomas-on-renal-biopsy-a-diagnostic-challenge",
        "language": "en",
        "issued": {
            "date-parts": [
                [
                    2026
                ]
            ]
        },
        "container-title": "Sultan Qaboos University Medical Journal",
        "volume": "26",
        "issue": "1",
        "page": "466-471",
        "DOI": "10.18295/2075-0528.3004",
        "publisher": "Sultan Qaboos University",
        "ISSN": "2075-051X",
        "abstract": "Sarcoidosis is an idiopathic multisystem inflammatory disorder characterised by non-caseating granulomas and a wide range of reported prevalence. Renal-limited sarcoidosis is a rare manifestation of sarcoidosis which remains a diagnostic challenge due to lack of extra renal manifestation and specific diagnostic criteria. We report a 37-year-old man who presented to a tertiary care hospital, Muscat, Oman, in 2024, with a two-month history of fever, weight loss, hypercalcaemia, high-to-normal 1,25-Vitamin D, high angiotensin-converting enzyme levels and acute kidney injury. His renal biopsy showed evidence of tubulointerstitial nephritis without granulomas or nephrocalcinosis. After exclusion of infectious, malignant, drug- related and autoimmune causes, a probable diagnosis of renal-limited sarcoidosis was considered. The patient received a course of steroids with subsequent improvement in his symptoms, renal function and renal biopsy inflammatory activity. This case highlights the diagnostic uncertainty and challenges in renal-limited sarcoidosis, particularly in the absence of granulomatous inflammation."
    }
]