Abstract
Pharmacological interventions of diabetic gastroparesis (DG) constitute an essential element of a patient’s management. This article aimed to systematically review the available pharmacological approaches of DG, including their efficacy and safety. A total of 24 randomised clinical trials (RCTs) that investigated the efficacy and/or safety of medications targeting DG symptoms were identified using several online databases. Their results revealed that metoclopramide was the only approved drug for accelerating gastric emptying and improving disease symptoms. However, this medication may have several adverse effects on the cardiovascular and nervous systems, which might be resolved with a new intranasal preparation. Acceptable alternatives are oral domperidone for patients without cardiovascular risk factors or intravenous erythromycin for hospitalised patients. Preliminary data indicated that relamorelin and prucalopride are novel candidates that have proven to be effective and safe. Future RCTs should be conducted based on unified guidelines using universal diagnostic modalities to reveal reliable and comprehensive outcomes.
Publication details
- DOI
- 10.18295/squmj.2019.19.04.004
- Journal
- Sultan Qaboos University Medical Journal, 19(4), e291-304
- Publisher
- Sultan Qaboos University
- Open access
- Gold open access
- License
- CC BY-ND 4.0
Cite this article
APA 7
Asha, M. Z., & Khalil, S. F. (2025). Pharmacological Approaches to Diabetic Gastroparesis: A systematic review of randomised clinical trials. Sultan Qaboos University Medical Journal, 19(4), e291-304. https://doi.org/10.18295/squmj.2019.19.04.004
MLA 9
Asha, Mohammad Z., and Sundos FH Khalil. "Pharmacological Approaches to Diabetic Gastroparesis: A systematic review of randomised clinical trials." Sultan Qaboos University Medical Journal, vol. 19, no. 4, 2025, pp. e291-304. https://doi.org/10.18295/squmj.2019.19.04.004.
Chicago (author–date)
Asha, Mohammad Z., and Sundos FH Khalil. 2025. "Pharmacological Approaches to Diabetic Gastroparesis: A systematic review of randomised clinical trials." Sultan Qaboos University Medical Journal 19 (4): e291-304. https://doi.org/10.18295/squmj.2019.19.04.004.
Harvard
Asha, M. Z. and Khalil, S. F. (2025) 'Pharmacological Approaches to Diabetic Gastroparesis: A systematic review of randomised clinical trials', Sultan Qaboos University Medical Journal, 19(4), pp. e291-304. doi:10.18295/squmj.2019.19.04.004.
Vancouver
Asha MZ, Khalil SF. Pharmacological Approaches to Diabetic Gastroparesis: A systematic review of randomised clinical trials. Sultan Qaboos University Medical Journal. 2025;19(4):e291-304. doi:10.18295/squmj.2019.19.04.004
IEEE
M. Z. Asha, and S. F. Khalil, "Pharmacological Approaches to Diabetic Gastroparesis: A systematic review of randomised clinical trials," Sultan Qaboos University Medical Journal, vol. 19, no. 4, pp. e291-304, 2025, doi: 10.18295/squmj.2019.19.04.004.