Abstract
Objectives: Psoriasis is a chronic inflammatory skin disease. Chronic inflammation results in increased oxidative stress and oxidizes lipoproteins, increasing their atherogenicity. This study sought to estimate the levels of oxidized low-density lipoprotein (ox-LDL) and antibodies against oxidized LDL (anti-ox-LDL) and compute the ratio of anti-ox-LDL/ox-LDL as a single composite parameter to assess the oxidative lipoprotein burden as an indicator of cardiovascular risk in patients with psoriasis. Methods: This cross-sectional study included 45 patients with psoriasis. All patients were given a psoriasis severity index score and their ox-LDL and anti-ox-LDL estimated using ELISA. Results: The results of this study show an elevation in the ratio of anti-ox-LDL to ox-LDL in patients with psoriasis, which initiate and perpetuate the pathogenesis of psoriasis and its comorbidity, atherosclerotic cardiovascular disease. Conclusions: Our results suggest that an elevated ratio of anti-ox-LDL/ox-LDL can serve as a composite parameter reflecting the total oxidative lipoprotein burden and cardiovascular risk in psoriasis patients.
Keywords
Subject
Publication details
- DOI
- 10.5001/omj.2016.78
- Journal
- Oman Medical Journal
- Publisher
- Oman Medical Specialty Board
- Open access
- Gold open access
Cite this article
APA 7
S, S., Rajappa, M., Thappa, D. M., Chandrashekar, L., Munisamy, M., & Revathy, G. (2016). Is the Ratio of Antibodies Against Oxidized LDL to Oxidized LDL an Indicator of Cardiovascular Risk in Psoriasis? Oman Medical Journal. https://doi.org/10.5001/omj.2016.78
MLA 9
S, Sunitha, et al. "Is the Ratio of Antibodies Against Oxidized LDL to Oxidized LDL an Indicator of Cardiovascular Risk in Psoriasis?" Oman Medical Journal, 2016. https://doi.org/10.5001/omj.2016.78.
Chicago (author–date)
S, Sunitha, Medha Rajappa, Devinder Mohan Thappa, Laxmisha Chandrashekar, Malathi Munisamy, and G. Revathy. 2016. "Is the Ratio of Antibodies Against Oxidized LDL to Oxidized LDL an Indicator of Cardiovascular Risk in Psoriasis?" Oman Medical Journal. https://doi.org/10.5001/omj.2016.78.
Harvard
S, S., Rajappa, M., Thappa, D. M., Chandrashekar, L., Munisamy, M. and Revathy, G. (2016) 'Is the Ratio of Antibodies Against Oxidized LDL to Oxidized LDL an Indicator of Cardiovascular Risk in Psoriasis?', Oman Medical Journal. doi:10.5001/omj.2016.78.
Vancouver
S S, Rajappa M, Thappa DM, Chandrashekar L, Munisamy M, Revathy G. Is the Ratio of Antibodies Against Oxidized LDL to Oxidized LDL an Indicator of Cardiovascular Risk in Psoriasis? Oman Medical Journal. 2016. doi:10.5001/omj.2016.78
IEEE
S. S, M. Rajappa, D. M. Thappa, L. Chandrashekar, M. Munisamy, and G. Revathy, "Is the Ratio of Antibodies Against Oxidized LDL to Oxidized LDL an Indicator of Cardiovascular Risk in Psoriasis?," Oman Medical Journal, 2016, doi: 10.5001/omj.2016.78.