[
    {
        "id": "osp-1850",
        "type": "article-journal",
        "title": "Is the Ratio of Antibodies Against Oxidized LDL to Oxidized LDL an Indicator of Cardiovascular Risk in Psoriasis?",
        "author": [
            {
                "family": "S",
                "given": "Sunitha"
            },
            {
                "family": "Rajappa",
                "given": "Medha"
            },
            {
                "family": "Thappa",
                "given": "Devinder Mohan"
            },
            {
                "family": "Chandrashekar",
                "given": "Laxmisha"
            },
            {
                "family": "Munisamy",
                "given": "Malathi"
            },
            {
                "family": "Revathy",
                "given": "G."
            }
        ],
        "URL": "https://omanscience.com/en/articles/is-the-ratio-of-antibodies-against-oxidized-ldl-to-oxidized-ldl-an-indicator-of-cardiovascular-risk-in-psoriasis",
        "language": "en",
        "issued": {
            "date-parts": [
                [
                    2016
                ]
            ]
        },
        "container-title": "Oman Medical Journal",
        "DOI": "10.5001/omj.2016.78",
        "publisher": "Oman Medical Specialty Board",
        "ISSN": "1999-768X",
        "abstract": "Objectives: Psoriasis is a chronic inflammatory skin disease. Chronic inflammation results in increased oxidative stress and oxidizes lipoproteins, increasing their atherogenicity. This study sought to estimate the levels of oxidized low-density lipoprotein (ox-LDL) and antibodies against oxidized LDL (anti-ox-LDL) and compute the ratio of anti-ox-LDL/ox-LDL as a single composite parameter to assess the oxidative lipoprotein burden as an indicator of cardiovascular risk in patients with psoriasis. Methods: This cross-sectional study included 45 patients with psoriasis. All patients were given a psoriasis severity index score and their ox-LDL and anti-ox-LDL estimated using ELISA. Results: The results of this study show an elevation in the ratio of anti-ox-LDL to ox-LDL in patients with psoriasis, which initiate and perpetuate the pathogenesis of psoriasis and its comorbidity, atherosclerotic cardiovascular disease. Conclusions: Our results suggest that an elevated ratio of anti-ox-LDL/ox-LDL can serve as a composite parameter reflecting the total oxidative lipoprotein burden and cardiovascular risk in psoriasis patients."
    }
]