Abstract
Toxic epidermal necrolysis (TEN), an uncommon but potentially life-threatening skin reaction, is frequently induced by drugs. The mucocutaneous reaction is characterised by bullous detachment of the epidermis and mucous membranes. We present a 9-month-old male with methylmalonic acidaemia, generalised hypotonia, and global developmental delay. He presented with a 3-day history of fever, cough, shortness of breath, and vomiting. Eruption appeared after 5 days of vancomycin treatment. The eruption involved almost 60% of the total body surface area and both eyes. He was successfully treated with intravenous immunoglobulin (IVIG), antibiotics,and appropriate wound management and made a full recovery with negligible sequelae despite the severity of his disease. Important components of successful treatment include early recognition, intensive care, prompt withdrawal of the causative agent, early administration of IVIG, appropriate fluid resuscitation, and control of infection. IVIG might be beneficial in the treatment of TEN; however, controlled studies are needed to evaluate IVIG compared to other modalities.
Publication details
- DOI
- 10.18295/2075-0528.1441
- Journal
- Sultan Qaboos University Medical Journal, 13(1), 132-136
- Publisher
- Sultan Qaboos University
- Open access
- Gold open access
- License
- CC BY-ND 4.0
Cite this article
APA 7
El-Naggari, M. A., Javad, H., Abdelmogheth, A. P., & A., A. (2025). Intravenous Immunoglobulin in the Treatment of Vancomycin-Induced Toxic Epidermal Necrolysis. Sultan Qaboos University Medical Journal, 13(1), 132-136. https://doi.org/10.18295/2075-0528.1441
MLA 9
El-Naggari, Mohamed A., et al. "Intravenous Immunoglobulin in the Treatment of Vancomycin-Induced Toxic Epidermal Necrolysis." Sultan Qaboos University Medical Journal, vol. 13, no. 1, 2025, pp. 132-136. https://doi.org/10.18295/2075-0528.1441.
Chicago (author–date)
El-Naggari, Mohamed A., Hashim Javad, Alexander P. Abdelmogheth, and Anas A. 2025. "Intravenous Immunoglobulin in the Treatment of Vancomycin-Induced Toxic Epidermal Necrolysis." Sultan Qaboos University Medical Journal 13 (1): 132-136. https://doi.org/10.18295/2075-0528.1441.
Harvard
El-Naggari, M. A., Javad, H., Abdelmogheth, A. P. and A., A. (2025) 'Intravenous Immunoglobulin in the Treatment of Vancomycin-Induced Toxic Epidermal Necrolysis', Sultan Qaboos University Medical Journal, 13(1), pp. 132-136. doi:10.18295/2075-0528.1441.
Vancouver
El-Naggari MA, Javad H, Abdelmogheth AP, A. A. Intravenous Immunoglobulin in the Treatment of Vancomycin-Induced Toxic Epidermal Necrolysis. Sultan Qaboos University Medical Journal. 2025;13(1):132-136. doi:10.18295/2075-0528.1441
IEEE
M. A. El-Naggari, H. Javad, A. P. Abdelmogheth, and A. A., "Intravenous Immunoglobulin in the Treatment of Vancomycin-Induced Toxic Epidermal Necrolysis," Sultan Qaboos University Medical Journal, vol. 13, no. 1, pp. 132-136, 2025, doi: 10.18295/2075-0528.1441.