Abstract
Immunoglobulin G4-related disease (IgG4-RD) is an increasingly recognized immune-mediated condition comprised of a collection of disorders that share specific pathological, serological, and clinical features. IgG4-RD is a fibroinflammatory condition with a tendency to form tumors with inflammatory infiltrate with IgG4 rich plasma cells and elevation of serum IgG4, which may affect virtually every organ and tissue. IgG4-related ophthalmic disease may present as dacryoadenitis, myositis, or involvement of other orbital tissue. Hypophysitis or pachymeningitis may manifest as cranial neuropathies. The diagnosis of IgG4-RD is based on a typical clinical scenario, supportive laboratory test, expected radiological characteristics, and distinct histopathological and immunohistochemical features. Corticosteroids and immunosuppressives form the mainline treatment.
Keywords
Publication details
- DOI
- 10.5001/omj.2018.20
- Journal
- Oman Medical Journal
- Publisher
- Oman Medical Specialty Board
- Open access
- Gold open access
Cite this article
APA 7
Al-Mujaini, A., Al-Khabori, M., Shenoy, K., & Wali, U. (2018). Immunoglobulin G4-Related Disease: An Update. Oman Medical Journal. https://doi.org/10.5001/omj.2018.20
MLA 9
Al-Mujaini, Abdullah, et al. "Immunoglobulin G4-Related Disease: An Update." Oman Medical Journal, 2018. https://doi.org/10.5001/omj.2018.20.
Chicago (author–date)
Al-Mujaini, Abdullah, Murtadha Al-Khabori, Kashinatha Shenoy, and Upender Wali. 2018. "Immunoglobulin G4-Related Disease: An Update." Oman Medical Journal. https://doi.org/10.5001/omj.2018.20.
Harvard
Al-Mujaini, A., Al-Khabori, M., Shenoy, K. and Wali, U. (2018) 'Immunoglobulin G4-Related Disease: An Update', Oman Medical Journal. doi:10.5001/omj.2018.20.
Vancouver
Al-Mujaini A, Al-Khabori M, Shenoy K, Wali U. Immunoglobulin G4-Related Disease: An Update. Oman Medical Journal. 2018. doi:10.5001/omj.2018.20
IEEE
A. Al-Mujaini, M. Al-Khabori, K. Shenoy, and U. Wali, "Immunoglobulin G4-Related Disease: An Update," Oman Medical Journal, 2018, doi: 10.5001/omj.2018.20.