Abstract
Interstitial cells of cajal (ICC) are specialised cells located within the musculature of the gastrointestinal tract (GIT). Although they form only 5% of the cells in the musculature of the GIT, they play a critical role in regulating smooth muscle function and GIT motility in coordination with the enteric nervous system. C-kit is a transmembrane glycoprotein that plays a critical role in ICC development and maturation. Physiological conditions such as ageing, as well as pathological conditions that have different disease processes, negatively affect ICC networks and function. Absent or disordered ICC networks can be associated with disorders in GIT motility. This review highlights the mechanism of ICC recovery from various types of injury which entails understanding the development of ICC and the factors affecting it. ICC transformation into malignant tumours (gastrointestinal stromal tumours) and their potential as contributors to therapeutic resistance is also discussed.
Publication details
- DOI
- 10.18295/2075-0528.1400
- Journal
- Sultan Qaboos University Medical Journal, 12(4), 411-421
- Publisher
- Sultan Qaboos University
- Open access
- Gold open access
- License
- CC BY-ND 4.0
Cite this article
APA 7
Al Sajee, D., & Huizinga, J. D. (2025). Interstitial Cells of Cajal: Pathology, injury and repair. Sultan Qaboos University Medical Journal, 12(4), 411-421. https://doi.org/10.18295/2075-0528.1400
MLA 9
Al Sajee, Dhuha, and Jan D. Huizinga. "Interstitial Cells of Cajal: Pathology, injury and repair." Sultan Qaboos University Medical Journal, vol. 12, no. 4, 2025, pp. 411-421. https://doi.org/10.18295/2075-0528.1400.
Chicago (author–date)
Al Sajee, Dhuha, and Jan D. Huizinga. 2025. "Interstitial Cells of Cajal: Pathology, injury and repair." Sultan Qaboos University Medical Journal 12 (4): 411-421. https://doi.org/10.18295/2075-0528.1400.
Harvard
Al Sajee, D. and Huizinga, J. D. (2025) 'Interstitial Cells of Cajal: Pathology, injury and repair', Sultan Qaboos University Medical Journal, 12(4), pp. 411-421. doi:10.18295/2075-0528.1400.
Vancouver
Al Sajee D, Huizinga JD. Interstitial Cells of Cajal: Pathology, injury and repair. Sultan Qaboos University Medical Journal. 2025;12(4):411-421. doi:10.18295/2075-0528.1400
IEEE
D. Al Sajee, and J. D. Huizinga, "Interstitial Cells of Cajal: Pathology, injury and repair," Sultan Qaboos University Medical Journal, vol. 12, no. 4, pp. 411-421, 2025, doi: 10.18295/2075-0528.1400.