الملخص
Interstitial cells of cajal (ICC) are specialised cells located within the musculature of the gastrointestinal tract (GIT). Although they form only 5% of the cells in the musculature of the GIT, they play a critical role in regulating smooth muscle function and GIT motility in coordination with the enteric nervous system. C-kit is a transmembrane glycoprotein that plays a critical role in ICC development and maturation. Physiological conditions such as ageing, as well as pathological conditions that have different disease processes, negatively affect ICC networks and function. Absent or disordered ICC networks can be associated with disorders in GIT motility. This review highlights the mechanism of ICC recovery from various types of injury which entails understanding the development of ICC and the factors affecting it. ICC transformation into malignant tumours (gastrointestinal stromal tumours) and their potential as contributors to therapeutic resistance is also discussed.
بيانات النشر
- المعرّف الرقمي
- 10.18295/2075-0528.1400
- المجلة
- مجلة جامعة السلطان قابوس الطبية, 12(4), 411-421
- الناشر
- جامعة السلطان قابوس
- وصول مفتوح
- وصول مفتوح ذهبي
- الترخيص
- CC BY-ND 4.0
اقتبس هذه المقالة
APA 7
Al Sajee, D., & Huizinga, J. D. (2025). Interstitial Cells of Cajal: Pathology, injury and repair. Sultan Qaboos University Medical Journal, 12(4), 411-421. https://doi.org/10.18295/2075-0528.1400
MLA 9
Al Sajee, Dhuha, and Jan D. Huizinga. "Interstitial Cells of Cajal: Pathology, injury and repair." Sultan Qaboos University Medical Journal, vol. 12, no. 4, 2025, pp. 411-421. https://doi.org/10.18295/2075-0528.1400.
شيكاغو (المؤلف–التاريخ)
Al Sajee, Dhuha, and Jan D. Huizinga. 2025. "Interstitial Cells of Cajal: Pathology, injury and repair." Sultan Qaboos University Medical Journal 12 (4): 411-421. https://doi.org/10.18295/2075-0528.1400.
هارفارد
Al Sajee, D. and Huizinga, J. D. (2025) 'Interstitial Cells of Cajal: Pathology, injury and repair', Sultan Qaboos University Medical Journal, 12(4), pp. 411-421. doi:10.18295/2075-0528.1400.
فانكوفر
Al Sajee D, Huizinga JD. Interstitial Cells of Cajal: Pathology, injury and repair. Sultan Qaboos University Medical Journal. 2025;12(4):411-421. doi:10.18295/2075-0528.1400
IEEE
D. Al Sajee, and J. D. Huizinga, "Interstitial Cells of Cajal: Pathology, injury and repair," Sultan Qaboos University Medical Journal, vol. 12, no. 4, pp. 411-421, 2025, doi: 10.18295/2075-0528.1400.