Abstract
Objectives: Toxoplasma gondii is a worldwide prevalent zoonotic parasite which causes toxoplasmosis. An appropriate vaccine for animals could interrupt the circle between animals and humans. Our previous study showed that excreted/secreted antigens (E/SA), derived from the peritoneum of mice infected with T. gondii tachyzoites could be considered as a good candidate for animal vaccination. Interleukin-10 (IL-10) inhibits proliferation of B and T lymphocytes and induces homeostasis in immune system responses. However, since IL-10 has also been shown to suppress the killing of T. gondii by human macrophages, the aim of this study was to evaluate IL-10 serum levels after vaccination with T. gondii E/SA prepared in vivo. Methods: T. gondii tachyzoites were inoculated in the peritoneum of mice and harvested E/SA were used as a vaccine, with and without adjuvant, in T. gondii infected and un-infected mice. IL-10 serum levels were evaluated using the ELISA technique. Results: The data showed that although serum levels of IL-10 were not changed at the early phases, they were elevated at the end phases of vaccination with T. gondii E/SA. Conclusion: Based on these and our previous results, it can be concluded that in vivo prepared T. gondii E/SA could be considered as a good candidate for animal vaccination.
Keywords
Publication details
- DOI
- 10.5001/omj.2013.29
- Journal
- Oman Medical Journal
- Publisher
- Oman Medical Specialty Board
- Open access
- Gold open access
Cite this article
APA 7
Abdollahi, S. H., Ayoobi, F., Khorramdelazad, H., Hassanshahi, G., Ahmadabadi, B. N., Rezayati, M., Ravary, A., Shamsizadeh, A., & Arababadi, M. K. (2013). Interleukin-10 Serum Levels after Vaccination with In Vivo Prepared Toxoplasma gondii Excreted/Secreted Antigens. Oman Medical Journal. https://doi.org/10.5001/omj.2013.29
MLA 9
Abdollahi, Seyed Hossein, et al. "Interleukin-10 Serum Levels after Vaccination with In Vivo Prepared Toxoplasma gondii Excreted/Secreted Antigens." Oman Medical Journal, 2013. https://doi.org/10.5001/omj.2013.29.
Chicago (author–date)
Abdollahi, Seyed Hossein, Fateme Ayoobi, Hossein Khorramdelazad, Gholamhossein Hassanshahi, Behzad Nasiri Ahmadabadi, Mohammadtaghi Rezayati, Ali Ravary, Ali Shamsizadeh, and Mohammad Kazemi Arababadi. 2013. "Interleukin-10 Serum Levels after Vaccination with In Vivo Prepared Toxoplasma gondii Excreted/Secreted Antigens." Oman Medical Journal. https://doi.org/10.5001/omj.2013.29.
Harvard
Abdollahi, S. H., Ayoobi, F., Khorramdelazad, H., Hassanshahi, G., Ahmadabadi, B. N., Rezayati, M., Ravary, A., Shamsizadeh, A. and Arababadi, M. K. (2013) 'Interleukin-10 Serum Levels after Vaccination with In Vivo Prepared Toxoplasma gondii Excreted/Secreted Antigens', Oman Medical Journal. doi:10.5001/omj.2013.29.
Vancouver
Abdollahi SH, Ayoobi F, Khorramdelazad H, Hassanshahi G, Ahmadabadi BN, Rezayati M, et al. Interleukin-10 Serum Levels after Vaccination with In Vivo Prepared Toxoplasma gondii Excreted/Secreted Antigens. Oman Medical Journal. 2013. doi:10.5001/omj.2013.29
IEEE
S. H. Abdollahi, F. Ayoobi, H. Khorramdelazad, G. Hassanshahi, B. N. Ahmadabadi, M. Rezayati, A. Ravary, A. Shamsizadeh, and M. K. Arababadi, "Interleukin-10 Serum Levels after Vaccination with In Vivo Prepared Toxoplasma gondii Excreted/Secreted Antigens," Oman Medical Journal, 2013, doi: 10.5001/omj.2013.29.