Abstract
Biotin is sometimes administered in mega doses to children to treat certain inborn errors of metabolism. We report the case of a one-week-old newborn who was started on a ‘mitochondrial cocktail’ that contained a high dose of biotin. On day seven of life, his thyroid function test showed a biochemical picture of primary hyperthyroidism, which was not clinically evident. The suspicion of immunoassay interference with thyroid function test was confirmed when another lab, using a different immunoassay, gave normal results. If the biochemical profile does not match the clinical picture, it is reasonable to doubt the test result and think of assay interference.
Keywords
Publication details
- DOI
- 10.5001/omj.2024.30
- Journal
- Oman Medical Journal
- Publisher
- Oman Medical Specialty Board
- Open access
- Gold open access
Cite this article
APA 7
Al Shibli, N., Al Shidhani, A., Ullah, I., AlSaffar, H., Al Kalbani, F., Al Farsi, K., AlShekaili, J., & Al-Riyami, N. (2024). Interference with Immunoassays of a Neonate on High Biotin: Case Report and Literature Review. Oman Medical Journal. https://doi.org/10.5001/omj.2024.30
MLA 9
Al Shibli, Naeema, et al. "Interference with Immunoassays of a Neonate on High Biotin: Case Report and Literature Review." Oman Medical Journal, 2024. https://doi.org/10.5001/omj.2024.30.
Chicago (author–date)
Al Shibli, Naeema, Azza Al Shidhani, Irfan Ullah, Hussain AlSaffar, Faris Al Kalbani, Koukab Al Farsi, Jalila AlShekaili, and Nafila Al-Riyami. 2024. "Interference with Immunoassays of a Neonate on High Biotin: Case Report and Literature Review." Oman Medical Journal. https://doi.org/10.5001/omj.2024.30.
Harvard
Al Shibli, N., Al Shidhani, A., Ullah, I., AlSaffar, H., Al Kalbani, F., Al Farsi, K., AlShekaili, J. and Al-Riyami, N. (2024) 'Interference with Immunoassays of a Neonate on High Biotin: Case Report and Literature Review', Oman Medical Journal. doi:10.5001/omj.2024.30.
Vancouver
Al Shibli N, Al Shidhani A, Ullah I, AlSaffar H, Al Kalbani F, Al Farsi K, et al. Interference with Immunoassays of a Neonate on High Biotin: Case Report and Literature Review. Oman Medical Journal. 2024. doi:10.5001/omj.2024.30
IEEE
N. Al Shibli, A. Al Shidhani, I. Ullah, H. AlSaffar, F. Al Kalbani, K. Al Farsi, J. AlShekaili, and N. Al-Riyami, "Interference with Immunoassays of a Neonate on High Biotin: Case Report and Literature Review," Oman Medical Journal, 2024, doi: 10.5001/omj.2024.30.