Abstract
As the world prevalence of diabetes mellitus (DM) increases, animal models of the disease's progression are required for researching effective treatment. The streptozotocin (STZ) treated rat is known to cause hyperglycaemia. This study confirms that this animal model also displays DM physiological effects in the animal heart rate (HR) and heart rate variability (HRV). In particular, 5 minutes of rat (n=13) electrocardiogram (ECG) is acquired hourly for 30 days. At day 10, the animal (n=7) is dosed with STZ and the ECG is analyzed in order to determine the HR and HRV. The HRV is indexed using two time-based analyses, based on long-term (24hr) and short-term (5min) analyses. All analyses are compared to control non-STZ dosed animals (n=6) and display significant DM effects.
Keywords
Publication details
- DOI
- 10.24200/tjer.vol4iss1pp64-68
- Journal
- The Journal of Engineering Research, 4(1), 64
- Publisher
- Sultan Qaboos University
- Open access
- Gold open access
- License
- CC BY 4.0
Cite this article
APA 7
Jacobson, M. L., Howarth, F. C., Adeghate, E., & Fatima-Shad, K. (2007). Heart Rate Variability Time Analyses of the Streptozotocin- Diabetic Rat. The Journal of Engineering Research, 4(1), 64. https://doi.org/10.24200/tjer.vol4iss1pp64-68
MLA 9
Jacobson, Michael L., et al. "Heart Rate Variability Time Analyses of the Streptozotocin- Diabetic Rat." The Journal of Engineering Research, vol. 4, no. 1, 2007, pp. 64. https://doi.org/10.24200/tjer.vol4iss1pp64-68.
Chicago (author–date)
Jacobson, Michael L., F. Chris Howarth, Ernest Adeghate, and Kaneez Fatima-Shad. 2007. "Heart Rate Variability Time Analyses of the Streptozotocin- Diabetic Rat." The Journal of Engineering Research 4 (1): 64. https://doi.org/10.24200/tjer.vol4iss1pp64-68.
Harvard
Jacobson, M. L., Howarth, F. C., Adeghate, E. and Fatima-Shad, K. (2007) 'Heart Rate Variability Time Analyses of the Streptozotocin- Diabetic Rat', The Journal of Engineering Research, 4(1), pp. 64. doi:10.24200/tjer.vol4iss1pp64-68.
Vancouver
Jacobson ML, Howarth FC, Adeghate E, Fatima-Shad K. Heart Rate Variability Time Analyses of the Streptozotocin- Diabetic Rat. The Journal of Engineering Research. 2007;4(1):64. doi:10.24200/tjer.vol4iss1pp64-68
IEEE
M. L. Jacobson, F. C. Howarth, E. Adeghate, and K. Fatima-Shad, "Heart Rate Variability Time Analyses of the Streptozotocin- Diabetic Rat," The Journal of Engineering Research, vol. 4, no. 1, pp. 64, 2007, doi: 10.24200/tjer.vol4iss1pp64-68.