Abstract
Objective: to determine the genotypes of arylamine N-acetyltransferase (NAT2) among 127 unrelated apparently healthy Omanis. Method: Identify the most common known polymorphisms of NAT*2 gene namely, G191A, C282T, C341T, C481T, G590A, A803G and G857A using PCR-RFLP analysis. Results: Eleven allele variants (3 alternative) and 30 different genotypes were determined. The commonest alleles were found to be NAT*5B, NAT2*6A and NAT*4 with corresponding frequencies of 0.362, 0.248 and 0.189 respectively. The overall frequency of rapid acetylator alleles was 0.25. Conclusion: A new allele variant containing G590A, C282T and T341C polymorphisms was found in one subject (was named NAT2*5J). The commonest genotypes were found to be 5B/5B, 5B/6A, 4/5B, 4/6A with frequencies 0.165, 0.157, 0.118, 0.110 and 0.079 respectively.
Publication details
- DOI
- 10.18295/2075-0528.2602
- Journal
- Sultan Qaboos University Medical Journal, 5(1), 9-14
- Publisher
- Sultan Qaboos University
- Open access
- Gold open access
- License
- CC BY-ND 4.0
Cite this article
APA 7
Tanira, M. O., Simsek, M., Al Lawatia, K., Khulood, Al Barawani, H., & Bayoumi, R. A. (2025). Distribution of arylamine N-acetyltransferase 2 (NAT2) genotypes among Omanis. Sultan Qaboos University Medical Journal, 5(1), 9-14. https://doi.org/10.18295/2075-0528.2602
MLA 9
Tanira, Musbah OM, et al. "Distribution of arylamine N-acetyltransferase 2 (NAT2) genotypes among Omanis." Sultan Qaboos University Medical Journal, vol. 5, no. 1, 2025, pp. 9-14. https://doi.org/10.18295/2075-0528.2602.
Chicago (author–date)
Tanira, Musbah OM, Mehmet Simsek, Khalid Al Lawatia, Khulood, Hameedah Al Barawani, and Riad A. Bayoumi. 2025. "Distribution of arylamine N-acetyltransferase 2 (NAT2) genotypes among Omanis." Sultan Qaboos University Medical Journal 5 (1): 9-14. https://doi.org/10.18295/2075-0528.2602.
Harvard
Tanira, M. O., Simsek, M., Al Lawatia, K., Khulood, Al Barawani, H. and Bayoumi, R. A. (2025) 'Distribution of arylamine N-acetyltransferase 2 (NAT2) genotypes among Omanis', Sultan Qaboos University Medical Journal, 5(1), pp. 9-14. doi:10.18295/2075-0528.2602.
Vancouver
Tanira MO, Simsek M, Al Lawatia K, Khulood, Al Barawani H, Bayoumi RA. Distribution of arylamine N-acetyltransferase 2 (NAT2) genotypes among Omanis. Sultan Qaboos University Medical Journal. 2025;5(1):9-14. doi:10.18295/2075-0528.2602
IEEE
M. O. Tanira, M. Simsek, K. Al Lawatia, Khulood, H. Al Barawani, and R. A. Bayoumi, "Distribution of arylamine N-acetyltransferase 2 (NAT2) genotypes among Omanis," Sultan Qaboos University Medical Journal, vol. 5, no. 1, pp. 9-14, 2025, doi: 10.18295/2075-0528.2602.