Abstract
Objective: To examine the correlation of lactase persistence phenotype with genotype in Omani adults. Methods: Lactase persistence phenotype was tested by hydrogen breath test in 52 Omani Adults using the Micro H2 analyzer. Results were checked against genotyping using direct DNA sequencing. Results: Forty one individuals with C/C-13910 and T/T-13915 genotypes had positive breath tests (≥20 ppm); while eight of nine individuals with T/C-13910 or T/G-13915 genotypes had negative breath tests (<20 ppm) and two subjects were non-hydrogen producers. The agreement between phenotype and genotype using Kappa value was very good (0.93). Conclusion: Genotyping both T/C-13910 and T/G-13915 alleles can be used to assist diagnosis and predict lactose intolerance in the Omani population.
Keywords
Publication details
- DOI
- 10.5001/omj.2013.98
- Journal
- Oman Medical Journal
- Publisher
- Oman Medical Specialty Board
- Open access
- Gold open access
Cite this article
APA 7
Al-Abri, A. R., & Bayoumi, R. (2013). The Phenotype/Genotype Correlation of Lactase Persistence among Omani Adults. Oman Medical Journal. https://doi.org/10.5001/omj.2013.98
MLA 9
Al-Abri, Abdul Rahim, and Riad Bayoumi. "The Phenotype/Genotype Correlation of Lactase Persistence among Omani Adults." Oman Medical Journal, 2013. https://doi.org/10.5001/omj.2013.98.
Chicago (author–date)
Al-Abri, Abdul Rahim, and Riad Bayoumi. 2013. "The Phenotype/Genotype Correlation of Lactase Persistence among Omani Adults." Oman Medical Journal. https://doi.org/10.5001/omj.2013.98.
Harvard
Al-Abri, A. R. and Bayoumi, R. (2013) 'The Phenotype/Genotype Correlation of Lactase Persistence among Omani Adults', Oman Medical Journal. doi:10.5001/omj.2013.98.
Vancouver
Al-Abri AR, Bayoumi R. The Phenotype/Genotype Correlation of Lactase Persistence among Omani Adults. Oman Medical Journal. 2013. doi:10.5001/omj.2013.98
IEEE
A. R. Al-Abri, and R. Bayoumi, "The Phenotype/Genotype Correlation of Lactase Persistence among Omani Adults," Oman Medical Journal, 2013, doi: 10.5001/omj.2013.98.