Abstract
X chromosome inactivation is the epitome of epigenetic regulation and long non-coding ribonucleic acid function. The differentiation status of cells has been ascribed to X chromosome activity, with two active X chromosomes generally only observed in undifferentiated or poorly differentiated cells. Recently, several studies have indicated that the reactivation of an inactive X chromosome or X chromosome multiplication correlates with the development of malignancy; however, this concept is still controversial. This review sought to shed light on the role of the X chromosome in cancer development. In particular, there is a need for further exploration of the expression patterns of X-linked genes in cancer cells, especially those in head and neck squamous cell carcinoma (HNSCC), in order to identify different prognostic subpopulations with distinct clinical implications. This article proposes a functional relationship between the loss of the Barr body and the disproportional expression of X-linked genes in HNSCC development.
Publication details
- DOI
- 10.18295/squmj.2017.17.04.003
- Journal
- Sultan Qaboos University Medical Journal, 17(4), 389-397
- Publisher
- Sultan Qaboos University
- Open access
- Gold open access
- License
- CC BY-ND 4.0
Cite this article
APA 7
Sharma, D., Koshy, G., Sharma, S., Bhushan, & Grover, S. (2025). Deciphering the Role of the Barr Body in Malignancy: An insight into head and neck cancer. Sultan Qaboos University Medical Journal, 17(4), 389-397. https://doi.org/10.18295/squmj.2017.17.04.003
MLA 9
Sharma, Deepti, et al. "Deciphering the Role of the Barr Body in Malignancy: An insight into head and neck cancer." Sultan Qaboos University Medical Journal, vol. 17, no. 4, 2025, pp. 389-397. https://doi.org/10.18295/squmj.2017.17.04.003.
Chicago (author–date)
Sharma, Deepti, George Koshy, Shruti Sharma, Bhushan, and Sonal Grover. 2025. "Deciphering the Role of the Barr Body in Malignancy: An insight into head and neck cancer." Sultan Qaboos University Medical Journal 17 (4): 389-397. https://doi.org/10.18295/squmj.2017.17.04.003.
Harvard
Sharma, D., Koshy, G., Sharma, S., Bhushan and Grover, S. (2025) 'Deciphering the Role of the Barr Body in Malignancy: An insight into head and neck cancer', Sultan Qaboos University Medical Journal, 17(4), pp. 389-397. doi:10.18295/squmj.2017.17.04.003.
Vancouver
Sharma D, Koshy G, Sharma S, Bhushan, Grover S. Deciphering the Role of the Barr Body in Malignancy: An insight into head and neck cancer. Sultan Qaboos University Medical Journal. 2025;17(4):389-397. doi:10.18295/squmj.2017.17.04.003
IEEE
D. Sharma, G. Koshy, S. Sharma, Bhushan, and S. Grover, "Deciphering the Role of the Barr Body in Malignancy: An insight into head and neck cancer," Sultan Qaboos University Medical Journal, vol. 17, no. 4, pp. 389-397, 2025, doi: 10.18295/squmj.2017.17.04.003.