[
    {
        "id": "osp-10815",
        "type": "article-journal",
        "title": "Deciphering the Role of the Barr Body in Malignancy: An insight into head and neck cancer",
        "author": [
            {
                "family": "Sharma",
                "given": "Deepti"
            },
            {
                "family": "Koshy",
                "given": "George"
            },
            {
                "family": "Sharma",
                "given": "Shruti"
            },
            {
                "family": "Bhushan",
                "given": ""
            },
            {
                "family": "Grover",
                "given": "Sonal"
            }
        ],
        "URL": "https://omanscience.com/en/articles/deciphering-the-role-of-the-barr-body-in-malignancy-an-insight-into-head-and-neck-cancer",
        "language": "en",
        "issued": {
            "date-parts": [
                [
                    2025
                ]
            ]
        },
        "container-title": "Sultan Qaboos University Medical Journal",
        "volume": "17",
        "issue": "4",
        "page": "389-397",
        "DOI": "10.18295/squmj.2017.17.04.003",
        "publisher": "Sultan Qaboos University",
        "ISSN": "2075-051X",
        "abstract": "X chromosome inactivation is the epitome of epigenetic regulation and long non-coding ribonucleic acid function. The differentiation status of cells has been ascribed to X chromosome activity, with two active X chromosomes generally only observed in undifferentiated or poorly differentiated cells. Recently, several studies have indicated that the reactivation of an inactive X chromosome or X chromosome multiplication correlates with the development of malignancy; however, this concept is still controversial. This review sought to shed light on the role of the X chromosome in cancer development. In particular, there is a need for further exploration of the expression patterns of X-linked genes in cancer cells, especially those in head and neck squamous cell carcinoma (HNSCC), in order to identify different prognostic subpopulations with distinct clinical implications. This article proposes a functional relationship between the loss of the Barr body and the disproportional expression of X-linked genes in HNSCC development."
    }
]