Abstract
The anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) usually manifests as systemic vasculitis. AAV with central nervous system involvement in the form of mesenrhombencephalitis and peripheral neuropathy is extremely rare. We report a 59-year-old male patient who presented to a tertiary care hospital in Muscat, Oman, in 2024. He had a subacute presentation of altered sensorium, multiple cranial nerve palsy and ataxia with 3 months history of bilateral foot drop. Brain imaging was suggestive of mesenrhombencephalitis with subarachnoid and intraparenchymal haemorrhage. Nerve conduction studies revealed sensorimotor axonal neuropathy. Vasculitis profile showed perinuclear-ANCA positivity and the nerve biopsy was suggestive of vasculitic neuropathy. He was treated with intravenous steroids and maintained on rituximab. His neurological deficits improved with residual bilateral foot drop.
Publication details
- DOI
- 10.18295/2075-0528.2820
- Journal
- Sultan Qaboos University Medical Journal, 25(1), 282-287
- Publisher
- Sultan Qaboos University
- Open access
- Gold open access
- License
- CC BY-ND 4.0
Cite this article
APA 7
Oommen, A. T., Gujjar, A. R., Al Jahdhami, S., Al-Asmi, A. R., & Sajjad, A. (2025). Anti-Neutrophil Cytoplasmic Antibody-Associated Central and Peripheral Nervous System Vasculitis. Sultan Qaboos University Medical Journal, 25(1), 282-287. https://doi.org/10.18295/2075-0528.2820
MLA 9
Oommen, Abel T., et al. "Anti-Neutrophil Cytoplasmic Antibody-Associated Central and Peripheral Nervous System Vasculitis." Sultan Qaboos University Medical Journal, vol. 25, no. 1, 2025, pp. 282-287. https://doi.org/10.18295/2075-0528.2820.
Chicago (author–date)
Oommen, Abel T., Arunodaya R. Gujjar, Suad Al Jahdhami, Abdullah R. Al-Asmi, and Ali Sajjad. 2025. "Anti-Neutrophil Cytoplasmic Antibody-Associated Central and Peripheral Nervous System Vasculitis." Sultan Qaboos University Medical Journal 25 (1): 282-287. https://doi.org/10.18295/2075-0528.2820.
Harvard
Oommen, A. T., Gujjar, A. R., Al Jahdhami, S., Al-Asmi, A. R. and Sajjad, A. (2025) 'Anti-Neutrophil Cytoplasmic Antibody-Associated Central and Peripheral Nervous System Vasculitis', Sultan Qaboos University Medical Journal, 25(1), pp. 282-287. doi:10.18295/2075-0528.2820.
Vancouver
Oommen AT, Gujjar AR, Al Jahdhami S, Al-Asmi AR, Sajjad A. Anti-Neutrophil Cytoplasmic Antibody-Associated Central and Peripheral Nervous System Vasculitis. Sultan Qaboos University Medical Journal. 2025;25(1):282-287. doi:10.18295/2075-0528.2820
IEEE
A. T. Oommen, A. R. Gujjar, S. Al Jahdhami, A. R. Al-Asmi, and A. Sajjad, "Anti-Neutrophil Cytoplasmic Antibody-Associated Central and Peripheral Nervous System Vasculitis," Sultan Qaboos University Medical Journal, vol. 25, no. 1, pp. 282-287, 2025, doi: 10.18295/2075-0528.2820.