نسخة أولية وصول مفتوح
Linear Fitness Subspace in Protein Language Models Enables Sample-Efficient Directed Evolution
Model-guided directed evolution seeks to identify high-fitness protein variants under limited oracle budgets. Protein language models (PLMs) provide rich representations for this task, but task-agnostic zero-shot scores can be misaligned with a target assay, while supervised search in high-dimensional embedding spaces …