الملخص
Objectives: This study aimed to determine the effects of propolis on immune mediators and tissue histopathology in rats with L-arginine-induced acute pancreatitis (AP). Methods: This study was conducted at Imam Abdulrahman Bin Faisal University, Dammam, Saudia Arabia between September and November 2017. A total of 24 male albino Wistar rats were divided into three equal groups. Group one was the negative control, group two was the positive control (L-arginine-induced AP) and group three received treatment (L-arginineinduced AP and propolis). The rats in group three were treated with 100 mg/kg propolis for seven days after AP induction. Pancreatic tissue was evaluated histologically and levels of interleukin (IL)-6, IL-22 and IL-1β and tumour necrosis factor-alpha (TNF-α) were measured. Results: Propolis reduced the quanitity of proinflammatory molecules (TNF-α, IL-1β and IL-6) in group three compared to group two, significantly increased the overall anti-inflammatory effect of IL-22 (P <0.005) and reduced interstitial inflammation and neutrophil cell infiltration of the pancreatic tissues. Conclusion: Propolis may exert a therapeutic effect in AP. Further studies are required to demonstrate the mechanisms of propolis in AP.
بيانات النشر
- المعرّف الرقمي
- 10.18295/squmj.2019.19.02.004
- المجلة
- مجلة جامعة السلطان قابوس الطبية, 19(2), e103-107
- الناشر
- جامعة السلطان قابوس
- وصول مفتوح
- وصول مفتوح ذهبي
- الترخيص
- CC BY-ND 4.0
اقتبس هذه المقالة
APA 7
Al-Hariri, M. T., Eldin, T. G., Chathoth, T., Shahanas, & Alswied, A. (2025). Propolis Modulates Inflammatory Mediators and Improves Histopathology in Male Rats with L-arginine-induced Acute Pancreatitis. Sultan Qaboos University Medical Journal, 19(2), e103-107. https://doi.org/10.18295/squmj.2019.19.02.004
MLA 9
Al-Hariri, Mohammed T., et al. "Propolis Modulates Inflammatory Mediators and Improves Histopathology in Male Rats with L-arginine-induced Acute Pancreatitis." Sultan Qaboos University Medical Journal, vol. 19, no. 2, 2025, pp. e103-107. https://doi.org/10.18295/squmj.2019.19.02.004.
شيكاغو (المؤلف–التاريخ)
Al-Hariri, Mohammed T., Tharwat G. Eldin, Tarek Chathoth, Shahanas, and Abdullah Alswied. 2025. "Propolis Modulates Inflammatory Mediators and Improves Histopathology in Male Rats with L-arginine-induced Acute Pancreatitis." Sultan Qaboos University Medical Journal 19 (2): e103-107. https://doi.org/10.18295/squmj.2019.19.02.004.
هارفارد
Al-Hariri, M. T., Eldin, T. G., Chathoth, T., Shahanas and Alswied, A. (2025) 'Propolis Modulates Inflammatory Mediators and Improves Histopathology in Male Rats with L-arginine-induced Acute Pancreatitis', Sultan Qaboos University Medical Journal, 19(2), pp. e103-107. doi:10.18295/squmj.2019.19.02.004.
فانكوفر
Al-Hariri MT, Eldin TG, Chathoth T, Shahanas, Alswied A. Propolis Modulates Inflammatory Mediators and Improves Histopathology in Male Rats with L-arginine-induced Acute Pancreatitis. Sultan Qaboos University Medical Journal. 2025;19(2):e103-107. doi:10.18295/squmj.2019.19.02.004
IEEE
M. T. Al-Hariri, T. G. Eldin, T. Chathoth, Shahanas, and A. Alswied, "Propolis Modulates Inflammatory Mediators and Improves Histopathology in Male Rats with L-arginine-induced Acute Pancreatitis," Sultan Qaboos University Medical Journal, vol. 19, no. 2, pp. e103-107, 2025, doi: 10.18295/squmj.2019.19.02.004.