[
    {
        "id": "osp-10577",
        "type": "article-journal",
        "title": "Propolis Modulates Inflammatory Mediators and Improves Histopathology in Male Rats with L-arginine-induced Acute Pancreatitis",
        "author": [
            {
                "family": "Al-Hariri",
                "given": "Mohammed T."
            },
            {
                "family": "Eldin",
                "given": "Tharwat G."
            },
            {
                "family": "Chathoth",
                "given": "Tarek"
            },
            {
                "family": "Shahanas",
                "given": ""
            },
            {
                "family": "Alswied",
                "given": "Abdullah"
            }
        ],
        "URL": "https://omanscience.com/ar/articles/propolis-modulates-inflammatory-mediators-and-improves-histopathology-in-male-rats-with-l-arginine-induced-acute-pancreatitis",
        "language": "en",
        "issued": {
            "date-parts": [
                [
                    2025
                ]
            ]
        },
        "container-title": "Sultan Qaboos University Medical Journal",
        "volume": "19",
        "issue": "2",
        "page": "e103-107",
        "DOI": "10.18295/squmj.2019.19.02.004",
        "publisher": "Sultan Qaboos University",
        "ISSN": "2075-051X",
        "abstract": "Objectives: This study aimed to determine the effects of propolis on immune mediators and tissue histopathology in rats with L-arginine-induced acute pancreatitis (AP). Methods: This study was conducted at Imam Abdulrahman Bin Faisal University, Dammam, Saudia Arabia between September and November 2017. A total of 24 male albino Wistar rats were divided into three equal groups. Group one was the negative control, group two was the positive control (L-arginine-induced AP) and group three received treatment (L-arginineinduced AP and propolis). The rats in group three were treated with 100 mg/kg propolis for seven days after AP induction. Pancreatic tissue was evaluated histologically and levels of interleukin (IL)-6, IL-22 and IL-1β and tumour necrosis factor-alpha (TNF-α) were measured. Results: Propolis reduced the quanitity of proinflammatory molecules (TNF-α, IL-1β and IL-6) in group three compared to group two, significantly increased the overall anti-inflammatory effect of IL-22 (P"
    }
]