الملخص
Background: This study aimed to assess the effect of low-level laser therapy (LLLT) and chia seeds on the mitigation of photoreceptors abnormalities in experimental diabetic retinopathy (DR). Materials and methods: A total of 65 female Wistar rats, 5 rats were served as a control group and 60 rats were injected intraperitoneally with one dose of 55 mg/kg of streptozotocin (STZ) to induce DR after 6-8 weeks. The rats were divided into (n = 20 rats each): (a) DR group: did not receive any treatment, (b) DR+ LLLT group was exposed to 670-nm LLLT for 6 weeks (two sessions/week), and (c) DR+ LLLT+ chia seed group, in which rats were exposed to LLLT and administrated with 250 mg/kg/day of chia seeds flour for 2 weeks before STZ injection and continued to the end of the experiment. Blood glucose (BG) levels and retinal histological examination were employed after 1, 2, 4, and 6 weeks. Results: The BG level in the DR group and the treated groups were significantly higher (P < 0.001) than in the control group after the four-time periods. Chia seeds group exhibited BG levels less than the DR and the DR+ LLLT groups after 6 weeks (P < 0.01). LLLT improved the degeneration of the photoreceptors after 6 weeks of treatment, while LLLT+ chia seeds supplementation showed early photoreceptors improvement after 2 weeks. Conclusion: The early improvement in the photoreceptors after LLLT+ chia seed may be attributed to the potent antioxidant properties of chia seeds. Therefore, the combination between LLLT and chia seeds should be employed to protect the retinal photoreceptors against DR.
الكلمات المفتاحية
بيانات النشر
- المعرّف الرقمي
- 10.4103/ojo.ojo_251_21
- المجلة
- المجلة العُمانية لطب العيون, 15(3), 347-352
- الناشر
- منشورات ميدنو
- وصول مفتوح
- وصول مفتوح ذهبي
اقتبس هذه المقالة
APA 7
Mahmoud, A. R. H., Abdelkawi, S. A., Ghoneim, D. F., Hassan, A. A., & Morsy, M. E. (2022). Mitigation of photoreceptors abnormalities after low-level laser therapy and chia seeds supplementation in experimental diabetic retinopathy. Oman Journal of Ophthalmology, 15(3), 347-352. https://doi.org/10.4103/ojo.ojo_251_21
MLA 9
Mahmoud, Abdel Rahman Hassan, et al. "Mitigation of photoreceptors abnormalities after low-level laser therapy and chia seeds supplementation in experimental diabetic retinopathy." Oman Journal of Ophthalmology, vol. 15, no. 3, 2022, pp. 347-352. https://doi.org/10.4103/ojo.ojo_251_21.
شيكاغو (المؤلف–التاريخ)
Mahmoud, Abdel Rahman Hassan, Salwa Ahmed Abdelkawi, Dina Fouad Ghoneim, Aziza Ahmed Hassan, and Mona Ebrahim Morsy. 2022. "Mitigation of photoreceptors abnormalities after low-level laser therapy and chia seeds supplementation in experimental diabetic retinopathy." Oman Journal of Ophthalmology 15 (3): 347-352. https://doi.org/10.4103/ojo.ojo_251_21.
هارفارد
Mahmoud, A. R. H., Abdelkawi, S. A., Ghoneim, D. F., Hassan, A. A. and Morsy, M. E. (2022) 'Mitigation of photoreceptors abnormalities after low-level laser therapy and chia seeds supplementation in experimental diabetic retinopathy', Oman Journal of Ophthalmology, 15(3), pp. 347-352. doi:10.4103/ojo.ojo_251_21.
فانكوفر
Mahmoud ARH, Abdelkawi SA, Ghoneim DF, Hassan AA, Morsy ME. Mitigation of photoreceptors abnormalities after low-level laser therapy and chia seeds supplementation in experimental diabetic retinopathy. Oman Journal of Ophthalmology. 2022;15(3):347-352. doi:10.4103/ojo.ojo_251_21
IEEE
A. R. H. Mahmoud, S. A. Abdelkawi, D. F. Ghoneim, A. A. Hassan, and M. E. Morsy, "Mitigation of photoreceptors abnormalities after low-level laser therapy and chia seeds supplementation in experimental diabetic retinopathy," Oman Journal of Ophthalmology, vol. 15, no. 3, pp. 347-352, 2022, doi: 10.4103/ojo.ojo_251_21.