الملخص
Objectives: To evaluate the levels of circulating erythrocyte-derived microparticles (EMPs) and platelet-derived microparticles (PMPs)in children with non-transfusion-dependent beta-thalassemia (NTDT), and explore their contribution to hypercoagulability. Methods: This case-control study included 50 children diagnosed with NTDT and 50 age- and sex-matched healthy controls. The children were recruited from the hematology/oncology unit of Alexandria University Children’s Hospital, Egypt from November 2022 to May 2023. Results: The percentage of EMPs and PMPs was significantly higher in NTDT patients compared with healthy controls. Serum B-type natriuretic peptide was higher in NTDT patients compared to controls; however, it didn’t reach a statistical significance. Conclusions: The significantly higher levels of EMPs and PMPs in NTDT patients may contribute to the hypercoagulable state associated with the disease. Measurement of proB-type natriuretic peptide, though not statistically significant in this cohort, may hold potential as an early biomarker for pulmonary hypertension in NTDT patients, for which larger prospective studies are recommended.
الكلمات المفتاحية
بيانات النشر
- المعرّف الرقمي
- 10.5001/omj.2025.85
- المجلة
- مجلة عُمان الطبية, 40(4)
- الناشر
- المجلس العُماني للاختصاصات الطبية
- وصول مفتوح
- وصول مفتوح ذهبي
- الترخيص
- CC BY-NC 4.0
اقتبس هذه المقالة
APA 7
El-Domiaty, B., Salama, M., Mikhael, N. L., Donia, H., Khalil, W. M., & Hassanein, N. M. (2025). Circulating Red Cell and Platelet Microparticles in Pediatric Non-transfusion Dependent Betathalassemia: A Case Control Study. Oman Medical Journal, 40(4). https://doi.org/10.5001/omj.2025.85
MLA 9
El-Domiaty, Bothaina, et al. "Circulating Red Cell and Platelet Microparticles in Pediatric Non-transfusion Dependent Betathalassemia: A Case Control Study." Oman Medical Journal, vol. 40, no. 4, 2025. https://doi.org/10.5001/omj.2025.85.
شيكاغو (المؤلف–التاريخ)
El-Domiaty, Bothaina, Moustafa Salama, Neveen Lewis Mikhael, Hanaa Donia, Wessam Mohamed Khalil, and Nehad Mohamed Hassanein. 2025. "Circulating Red Cell and Platelet Microparticles in Pediatric Non-transfusion Dependent Betathalassemia: A Case Control Study." Oman Medical Journal 40 (4). https://doi.org/10.5001/omj.2025.85.
هارفارد
El-Domiaty, B., Salama, M., Mikhael, N. L., Donia, H., Khalil, W. M. and Hassanein, N. M. (2025) 'Circulating Red Cell and Platelet Microparticles in Pediatric Non-transfusion Dependent Betathalassemia: A Case Control Study', Oman Medical Journal, 40(4). doi:10.5001/omj.2025.85.
فانكوفر
El-Domiaty B, Salama M, Mikhael NL, Donia H, Khalil WM, Hassanein NM. Circulating Red Cell and Platelet Microparticles in Pediatric Non-transfusion Dependent Betathalassemia: A Case Control Study. Oman Medical Journal. 2025;40(4). doi:10.5001/omj.2025.85
IEEE
B. El-Domiaty, M. Salama, N. L. Mikhael, H. Donia, W. M. Khalil, and N. M. Hassanein, "Circulating Red Cell and Platelet Microparticles in Pediatric Non-transfusion Dependent Betathalassemia: A Case Control Study," Oman Medical Journal, vol. 40, no. 4, 2025, doi: 10.5001/omj.2025.85.