Research article Open access
Cytotoxic Effect of Soluble TRAIL and Its Combination with Irinotecan on the Chemoresistance of Colorectal Cancer
Colorectal cancer (CRC) presents high incidence and mortality, largely due to late diagnosis and the persistence of cancer stem cells (CSCs), which contribute to chemoresistance and poor patient outcomes. TRAIL (TNF-related apoptosis-inducing ligand) is considered a promising therapeutic agent because of its ability to …