Preprint Open access
Large language models (LLMs) have shown promise in medical question answering and clinical reasoning, yet their improvement remains constrained by static parametric knowledge and costly expert supervision. Self-evolving agents offer a promising alternative by enabling models to improve through iterative task generation …
Preprint Open access
The central challenge in de novo protein design is generating plausible, mutually compatible structures and sequences, such that each designed sequence folds into its intended structure and the structure accommodates that sequence. Compared to typical two-stage design methods, which decouple the modeling of the interde …
Preprint Open access
Predicting gene expression from H&E-stained histology images offers a scalable alternative to costly spatial transcriptomics, yet most existing methods operate at the spot level, where signals from multiple cells are aggregated and critical cellular heterogeneity is obscured. Extending this paradigm to single-cell reso …
Preprint Open access
Instruction-guided video editing has made significant progress, yet existing methods use multimodal large language models (MLLMs) primarily as semantic encoders, so they often fall short in working with implicit edits that require causal or semantic reasoning. To bridge this fundamental gap in video editing, we propose …
Preprint Open access
Robotic bin packing requires long-horizon sequential decision-making, as each object placement affects the available space for subsequent packing. Existing methods primarily rely on hand-crafted geometric heuristics that optimize predefined objectives or reinforcement learning policies learned through trial and error o …
Preprint Open access
World modeling enables intelligence to anticipate consequences, guide interventions, and learn from interaction. Yet predictive models remain domain-specific: can a common learning principle support world modeling across radically different systems? We introduce JEPA-Anything, a domain-agnostic framework based on ortho …