Research article Open access
Cardiovascular Responses to Tonic Pain in REM Sleep-Deprived Rats Role of Melatonin and Beta Endorphin
Objective: Chronic pain is associated with increased incidence of hypertension. Sleep deprivation, common in patients with chronic pain, is associated with increased blood pressure and heart rate. This study was designed to determine whether sleep deprivation induces increased cardiovascular responses to pain. In addit …