Abstract
Xeroderma pigmentosum is an uncommon inherited autosomal recessive disorder. Affected patients have a 2000-fold amplified risk of skin cancer. There is an inability to repair the damage to genetic material caused by ultraviolet light. Basal cell carcinoma is the most commonly associated carcinoma followed by squamous cell carcinoma and melanoma. It is a highly mutilating disorder where occurrence of multiple cancers and repeated surgical treatments result in serious psycho-social implications. We present a case of diagnosed xeroderma pigmentosum in a 25 year old male who presented with multiple lesions and non-healing ulcers on face. Four surgical specimens from left lower eyelid, chin, right cheek and upper lip were taken for histopathological diagnosis. Microscopic examination revealed five different tumors from biopsies of these sites - specimen from right cheek revealed two morphologically distinct tumors. The tumors include basosquamous carcinoma, nodular basal cell carcinoma, adenoid basal cell carcinoma, malignant melanoma and cavernous hemangioma.
Keywords
Publication details
- DOI
- 10.5001/omj.2014.64
- Journal
- Oman Medical Journal
- Publisher
- Oman Medical Specialty Board
- Open access
- Gold open access
Cite this article
APA 7
Shams, M. U., Lail, R. A., Ullah, E., & Nagi, A. H. (2014). Xeroderma Pigmentosum - a disfiguring disease: Single patient with 5 simultaneous tumors on face. Oman Medical Journal. https://doi.org/10.5001/omj.2014.64
MLA 9
Shams, Muhammad Usman, et al. "Xeroderma Pigmentosum - a disfiguring disease: Single patient with 5 simultaneous tumors on face." Oman Medical Journal, 2014. https://doi.org/10.5001/omj.2014.64.
Chicago (author–date)
Shams, Muhammad Usman, Raees Abbas Lail, Ehsan Ullah, and Abdul Hannan Nagi. 2014. "Xeroderma Pigmentosum - a disfiguring disease: Single patient with 5 simultaneous tumors on face." Oman Medical Journal. https://doi.org/10.5001/omj.2014.64.
Harvard
Shams, M. U., Lail, R. A., Ullah, E. and Nagi, A. H. (2014) 'Xeroderma Pigmentosum - a disfiguring disease: Single patient with 5 simultaneous tumors on face', Oman Medical Journal. doi:10.5001/omj.2014.64.
Vancouver
Shams MU, Lail RA, Ullah E, Nagi AH. Xeroderma Pigmentosum - a disfiguring disease: Single patient with 5 simultaneous tumors on face. Oman Medical Journal. 2014. doi:10.5001/omj.2014.64
IEEE
M. U. Shams, R. A. Lail, E. Ullah, and A. H. Nagi, "Xeroderma Pigmentosum - a disfiguring disease: Single patient with 5 simultaneous tumors on face," Oman Medical Journal, 2014, doi: 10.5001/omj.2014.64.