Abstract
Alzheimer’s disease (AD), a neurodegenerative disorder associated with advanced age, is the most common cause of dementia globally. AD is characterised by cognitive dysfunction, deposition of amyloid plaques, neurofibrillary tangles and neuro-inflammation. Inflammation of the brain is a key pathological hallmark of AD. Thus, clinical and immunopathological evidence of AD could be potentially supported by inflammatory mediators, including cytokines, chemokines, the complement system, acute phase proteins and oxidative mediators. In particular, oxidative mediators may actively contribute to the progression of AD and on-going inflammation in the brain. This review provides an overview of the functions and activities of inflammatory mediators in AD. An improved understanding of inflammatory processes and their role in AD is needed to improve therapeutic research aims in the field of AD and similar diseases.
Publication details
- DOI
- 10.18295/2075-0528.1699
- Journal
- Sultan Qaboos University Medical Journal, 15(3), 305-316
- Publisher
- Sultan Qaboos University
- Open access
- Gold open access
- License
- CC BY-ND 4.0
Cite this article
APA 7
Azizi, G., Navabi, S. S., Seyedzadeh, A., H., M., Yazdani, R., & Mirshafiey, A. (2025). The Role of Inflammatory Mediators in the Pathogenesis of Alzheimer’s Disease. Sultan Qaboos University Medical Journal, 15(3), 305-316. https://doi.org/10.18295/2075-0528.1699
MLA 9
Azizi, Gholamreza, et al. "The Role of Inflammatory Mediators in the Pathogenesis of Alzheimer’s Disease." Sultan Qaboos University Medical Journal, vol. 15, no. 3, 2025, pp. 305-316. https://doi.org/10.18295/2075-0528.1699.
Chicago (author–date)
Azizi, Gholamreza, Shadi S. Navabi, Ahmed Seyedzadeh, Mir H., Reza Yazdani, and Abbas Mirshafiey. 2025. "The Role of Inflammatory Mediators in the Pathogenesis of Alzheimer’s Disease." Sultan Qaboos University Medical Journal 15 (3): 305-316. https://doi.org/10.18295/2075-0528.1699.
Harvard
Azizi, G., Navabi, S. S., Seyedzadeh, A., H., M., Yazdani, R. and Mirshafiey, A. (2025) 'The Role of Inflammatory Mediators in the Pathogenesis of Alzheimer’s Disease', Sultan Qaboos University Medical Journal, 15(3), pp. 305-316. doi:10.18295/2075-0528.1699.
Vancouver
Azizi G, Navabi SS, Seyedzadeh A, H. M, Yazdani R, Mirshafiey A. The Role of Inflammatory Mediators in the Pathogenesis of Alzheimer’s Disease. Sultan Qaboos University Medical Journal. 2025;15(3):305-316. doi:10.18295/2075-0528.1699
IEEE
G. Azizi, S. S. Navabi, A. Seyedzadeh, M. H., R. Yazdani, and A. Mirshafiey, "The Role of Inflammatory Mediators in the Pathogenesis of Alzheimer’s Disease," Sultan Qaboos University Medical Journal, vol. 15, no. 3, pp. 305-316, 2025, doi: 10.18295/2075-0528.1699.