Abstract
Background: Decompensated cirrhosis patients have a high risk of death which can be considerably reduced with liver transplantation (LT). This study aimed to simultaneously investigate the effect of some patients' characteristics on mortality among those with/without LT and also LT incident. Materials and Methods: In this historical cohort study, the information from 780 eligible patients aged 18 years or older was analyzed by the Markov multistate model; they had been listed between 2008 and 2014, needed a single organ for initial orthotopic LT, and followed at least for up to 5 years. Results: With a median survival time of 6 (5-8) years, there were 275 (35%) deaths. From 255 (33%) patients who had LT, 55 (21%) subsequently died. Factors associated with a higher risk of mortality and LT occurrence were included: higher model for end-stage liver disease (MELD) score (hazard ratio [HR] = 1.16, confidence interval [CI]: 1.09-1.24 and HR = 1.22, CI: 1.41-1.30) and ascites complication (HR = 2.34, CI: 1.74-3.16 and HR = 11.43, CI: 8.64-15.12). Older age (HR = 1.03, CI: 1.01-1.06), higher creatinine (HR = 6.87, CI: 1.45-32.56), and autoimmune disease versus hepatitis (HR = 2.53, CI: 1.12-5.73) were associated with increased risk of mortality after LT. Conclusion: The MELD and ascites are influential factors on waiting list mortality and occurrence of LT. Total life expectancy is not influenced by higher MELD.
Keywords
Subject
Publication details
- DOI
- 10.4103/jrms.jrms_1091_21
- Journal
- Journal of Research in Medical Sciences, 28(1), 28
- Publisher
- Wolters Kluwer Medknow Publications
- Open access
- Gold open access
- License
- CC BY-NC-SA 4.0
Cite this article
APA 7
Madreseh, E., Mahmoudi, M., Toosi, M. N., Abolghasemi, J., & Zeraati, H. (2023). The effects of prognostic factors on transplant and mortality of patients with end-stage liver disease using Markov multistate model. Journal of Research in Medical Sciences, 28(1), 28. https://doi.org/10.4103/jrms.jrms_1091_21
MLA 9
Madreseh, Elham, et al. "The effects of prognostic factors on transplant and mortality of patients with end-stage liver disease using Markov multistate model." Journal of Research in Medical Sciences, vol. 28, no. 1, 2023, pp. 28. https://doi.org/10.4103/jrms.jrms_1091_21.
Chicago (author–date)
Madreseh, Elham, Mahmood Mahmoudi, Mohssen Nassiri Toosi, Jamileh Abolghasemi, and Hojjat Zeraati. 2023. "The effects of prognostic factors on transplant and mortality of patients with end-stage liver disease using Markov multistate model." Journal of Research in Medical Sciences 28 (1): 28. https://doi.org/10.4103/jrms.jrms_1091_21.
Harvard
Madreseh, E., Mahmoudi, M., Toosi, M. N., Abolghasemi, J. and Zeraati, H. (2023) 'The effects of prognostic factors on transplant and mortality of patients with end-stage liver disease using Markov multistate model', Journal of Research in Medical Sciences, 28(1), pp. 28. doi:10.4103/jrms.jrms_1091_21.
Vancouver
Madreseh E, Mahmoudi M, Toosi MN, Abolghasemi J, Zeraati H. The effects of prognostic factors on transplant and mortality of patients with end-stage liver disease using Markov multistate model. Journal of Research in Medical Sciences. 2023;28(1):28. doi:10.4103/jrms.jrms_1091_21
IEEE
E. Madreseh, M. Mahmoudi, M. N. Toosi, J. Abolghasemi, and H. Zeraati, "The effects of prognostic factors on transplant and mortality of patients with end-stage liver disease using Markov multistate model," Journal of Research in Medical Sciences, vol. 28, no. 1, pp. 28, 2023, doi: 10.4103/jrms.jrms_1091_21.