Abstract
Objectives: We sought to evaluate the effects of omega-3 and vitamin E co-supplementation on carotid intima-media thickness (CIMT) and inflammatory factors in patients with polycystic ovary syndrome (PCOS). Methods: This randomized, double-blind, placebo-controlled trial was done among 60 women with PCOS. Participants were randomly assigned into two groups (n = 30 each group) and assigned to take either 1000 mg omega-3 plus 400 IU vitamin E supplements or a placebo for 12 weeks. Results: Compared with placebo, omega-3 and vitamin E co-supplementation led to significant decreases in maximum levels of left CIMT (-0.006±0.006 vs. +0.002±0.007 mm, p < 0.001), mean levels of left CIMT (-0.005±0.006 vs. +0.002±0.010 mm, p = 0.010), maximum levels of right CIMT (-0.006±0.010 vs. +0.006±0.010 mm, p = 0.010), and mean levels of right CIMT (-0.005±0.005 vs. +0.001±0.010 mm, p = 0.020). Change in high-sensitivity C-reactive protein (hs-CRP) (-390.6±942.9 vs. +237.0±754.3 ng/mL, p = 0.006) was significantly different between the supplemented patients and placebo group. We did not observe any significant effect in plasma nitric oxide (NO) values following supplementation with omega-3 plus vitamin E compared with the placebo. Conclusions: Co-supplementation with omega-3 and vitamin E for 12 weeks among patients with PCOS had beneficial effects on CIMT and serum hs-CRP values, but unchanged NO values.
Keywords
Publication details
- DOI
- 10.5001/omj.2018.88
- Journal
- Oman Medical Journal
- Publisher
- Oman Medical Specialty Board
- Open access
- Gold open access
Cite this article
APA 7
Talari, H. R., Poladchang, S., Hamidian, Y., Samimi, M., Gilasi, H. R., Ebrahimi, F. A., & Asemi, Z. (2018). The Effects of Omega-3 and Vitamin E Co-supplementation on Carotid Intima-media Thickness and Inflammatory Factors in Patients with Polycystic Ovary Syndrome. Oman Medical Journal. https://doi.org/10.5001/omj.2018.88
MLA 9
Talari, Hamid Reza, et al. "The Effects of Omega-3 and Vitamin E Co-supplementation on Carotid Intima-media Thickness and Inflammatory Factors in Patients with Polycystic Ovary Syndrome." Oman Medical Journal, 2018. https://doi.org/10.5001/omj.2018.88.
Chicago (author–date)
Talari, Hamid Reza, Somayyeh Poladchang, Yaser Hamidian, Mansooreh Samimi, Hamid Reza Gilasi, Faraneh Afshar Ebrahimi, and Zatollah Asemi. 2018. "The Effects of Omega-3 and Vitamin E Co-supplementation on Carotid Intima-media Thickness and Inflammatory Factors in Patients with Polycystic Ovary Syndrome." Oman Medical Journal. https://doi.org/10.5001/omj.2018.88.
Harvard
Talari, H. R., Poladchang, S., Hamidian, Y., Samimi, M., Gilasi, H. R., Ebrahimi, F. A. and Asemi, Z. (2018) 'The Effects of Omega-3 and Vitamin E Co-supplementation on Carotid Intima-media Thickness and Inflammatory Factors in Patients with Polycystic Ovary Syndrome', Oman Medical Journal. doi:10.5001/omj.2018.88.
Vancouver
Talari HR, Poladchang S, Hamidian Y, Samimi M, Gilasi HR, Ebrahimi FA, et al. The Effects of Omega-3 and Vitamin E Co-supplementation on Carotid Intima-media Thickness and Inflammatory Factors in Patients with Polycystic Ovary Syndrome. Oman Medical Journal. 2018. doi:10.5001/omj.2018.88
IEEE
H. R. Talari, S. Poladchang, Y. Hamidian, M. Samimi, H. R. Gilasi, F. A. Ebrahimi, and Z. Asemi, "The Effects of Omega-3 and Vitamin E Co-supplementation on Carotid Intima-media Thickness and Inflammatory Factors in Patients with Polycystic Ovary Syndrome," Oman Medical Journal, 2018, doi: 10.5001/omj.2018.88.